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@ARTICLE{Roski:133020,
      author       = {Roski, Christian and Caspers, Svenja and Lux, Silke and
                      Hoffstaedter, Felix and Bergs, René and Amunts, Katrin and
                      Eickhoff, Simon},
      title        = {{A}ctivation shift in elderly subjects across functional
                      systems: an f{MRI} study.},
      journal      = {Brain structure $\&$ function},
      volume       = {219},
      number       = {2},
      issn         = {1863-2661},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2013-01588},
      pages        = {707-718},
      year         = {2014},
      abstract     = {The functional specificity of brain areas is diminished
                      with age and accompanied by the recruitment of additional
                      brain regions in healthy older adults. This process has
                      repeatedly been demonstrated within distinct functional
                      domains, in particular the visual system. However, it is yet
                      unclear, whether this phenomenon in healthy aging, i.e., a
                      reduced activation of task-associated areas and increased
                      activation of additional regions, is also present across
                      different functional systems. In the present functional
                      imaging study, comprising 102 healthy subjects, we therefore
                      assessed two distinct tasks engaging the sensory-motor
                      system and the visual attention system, respectively. We
                      found a significant interaction between age and task in the
                      parietal operculum bilaterally. This area as a part of the
                      sensory-motor system showed an age-related decrease in its
                      BOLD-response to the motor task and an age-related increase
                      of neural activity in response to the visual attention task.
                      The opposite response pattern, i.e., reduced visual
                      attention activation and increased response to the motor
                      task, was observed for regions associated with the visual
                      task: the superior parietal area 7A and the dorsal pre-motor
                      cortex. Importantly, task performance was not correlated
                      with age in either task. This age-by-task interaction
                      indicates that a reduction of functional specificity in the
                      aging brain may be counteracted by the increased recruitment
                      of additional regions not only within, but also across
                      functional domains. Our results thus emphasize the need for
                      comparisons across different functional domains to gain a
                      better understanding of age-related effects on the
                      specificity of functional systems.},
      cin          = {INM-1 / JARA-BRAIN / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-2-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / HASB - Helmholtz Alliance
                      on Systems Biology (HGF-SystemsBiology)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-Juel1)HGF-SystemsBiology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23455650},
      UT           = {WOS:000335737500019},
      doi          = {10.1007/s00429-013-0530-x},
      url          = {https://juser.fz-juelich.de/record/133020},
}