000134490 001__ 134490
000134490 005__ 20210129211656.0
000134490 0247_ $$2doi$$a10.3389/fnhum.2013.00232
000134490 0247_ $$2WOS$$aWOS:000319862700001
000134490 0247_ $$2Handle$$a2128/5182
000134490 0247_ $$2altmetric$$aaltmetric:1476247
000134490 0247_ $$2pmid$$apmid:23755001
000134490 037__ $$aFZJ-2013-02664
000134490 082__ $$a610
000134490 1001_ $$0P:(DE-Juel1)136848$$aBzdok, Danilo$$b0$$eCorresponding author
000134490 245__ $$aSegregation of the human medial prefrontal cortex in social cognition
000134490 260__ $$aLausanne$$bFrontiers Research Foundation$$c2013
000134490 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s134490
000134490 3367_ $$2DataCite$$aOutput Types/Journal article
000134490 3367_ $$00$$2EndNote$$aJournal Article
000134490 3367_ $$2BibTeX$$aARTICLE
000134490 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000134490 3367_ $$2DRIVER$$aarticle
000134490 500__ $$3POF3_Assignment on 2016-02-29
000134490 520__ $$aWhile the human medial prefrontal cortex (mPFC) is widely believed to be a key node of neural networks relevant for socio-emotional processing, its functional subspecialization is still poorly understood. We thus revisited the often assumed differentiation of the mPFC in social cognition along its ventral-dorsal axis. Our neuroinformatic analysis was based on a neuroimaging meta-analysis of perspective-taking that yielded two separate clusters in the ventral and dorsal mPFC, respectively. We determined each seed region's brain-wide interaction pattern by two complementary measures of functional connectivity: co-activation across a wide range of neuroimaging studies archived in the BrainMap database and correlated signal fluctuations during unconstrained (“resting”) cognition. Furthermore, we characterized the functions associated with these two regions using the BrainMap database. Across methods, the ventral mPFC was more strongly connected with the nucleus accumbens, hippocampus, posterior cingulate cortex, and retrosplenial cortex, while the dorsal mPFC was more strongly connected with the inferior frontal gyrus, temporo-parietal junction, and middle temporal gyrus. Further, the ventral mPFC was selectively associated with reward related tasks, while the dorsal mPFC was selectively associated with perspective-taking and episodic memory retrieval. The ventral mPFC is therefore predominantly involved in bottom-up-driven, approach/avoidance-modulating, and evaluation-related processing, whereas the dorsal mPFC is predominantly involved in top–down-driven, probabilistic-scene-informed, and metacognition-related processing in social cognition.
000134490 536__ $$0G:(DE-HGF)POF2-333$$a333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333)$$cPOF2-333$$fPOF II$$x0
000134490 536__ $$0G:(DE-Juel1)HGF-SystemsBiology$$aHASB - Helmholtz Alliance on Systems Biology (HGF-SystemsBiology)$$cHGF-SystemsBiology$$fHASB-2008-2012$$x1
000134490 588__ $$aDataset connected to CrossRef, juser.fz-juelich.de
000134490 7001_ $$0P:(DE-Juel1)131693$$aLangner, Robert$$b1
000134490 7001_ $$0P:(DE-HGF)0$$aSchilbach, Leonhard$$b2
000134490 7001_ $$0P:(DE-Juel1)144558$$aEngemann, Denis A.$$b3$$ufzj
000134490 7001_ $$0P:(DE-HGF)0$$aLaird, Angela R.$$b4
000134490 7001_ $$0P:(DE-HGF)0$$aFox, Peter T.$$b5
000134490 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b6
000134490 773__ $$0PERI:(DE-600)2425477-0$$a10.3389/fnhum.2013.00232$$gVol. 7$$n232$$p1-17$$tFrontiers in human neuroscience$$v7$$x1662-5161
000134490 8564_ $$uhttps://juser.fz-juelich.de/record/134490/files/FZJ-2013-02664.pdf$$yOpenAccess
000134490 8564_ $$uhttps://juser.fz-juelich.de/record/134490/files/FZJ-2013-02664.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
000134490 8564_ $$uhttps://juser.fz-juelich.de/record/134490/files/FZJ-2013-02664.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
000134490 8564_ $$uhttps://juser.fz-juelich.de/record/134490/files/FZJ-2013-02664.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
000134490 909__ $$ooai:juser.fz-juelich.de:134490$$pVDB
000134490 909__ $$ooai:juser.fz-juelich.de:134490$$pOA
000134490 909__ $$ooai:juser.fz-juelich.de:134490$$pOA
000134490 909CO $$ooai:juser.fz-juelich.de:134490$$pdnbdelivery$$pVDB$$pdriver$$popen_access$$popenaire
000134490 915__ $$0StatID:(DE-HGF)0010$$2StatID$$aJCR/ISI refereed
000134490 915__ $$0StatID:(DE-HGF)0020$$2StatID$$aNo Peer review
000134490 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000134490 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000134490 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000134490 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000134490 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000134490 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000134490 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000134490 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000134490 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000134490 9141_ $$y2013
000134490 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)136848$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
000134490 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131693$$aForschungszentrum Jülich GmbH$$b1$$kFZJ
000134490 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144558$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000134490 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich GmbH$$b6$$kFZJ
000134490 9132_ $$0G:(DE-HGF)POF3-579H$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vAddenda$$x0
000134490 9131_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000134490 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x0
000134490 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x1
000134490 980__ $$ajournal
000134490 980__ $$aUNRESTRICTED
000134490 980__ $$aJUWEL
000134490 980__ $$aFullTexts
000134490 980__ $$aI:(DE-Juel1)INM-1-20090406
000134490 980__ $$aI:(DE-Juel1)INM-3-20090406
000134490 980__ $$aVDB
000134490 9801_ $$aFullTexts
000134490 981__ $$aI:(DE-Juel1)INM-3-20090406