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@ARTICLE{Bzdok:134490,
      author       = {Bzdok, Danilo and Langner, Robert and Schilbach, Leonhard
                      and Engemann, Denis A. and Laird, Angela R. and Fox, Peter
                      T. and Eickhoff, Simon},
      title        = {{S}egregation of the human medial prefrontal cortex in
                      social cognition},
      journal      = {Frontiers in human neuroscience},
      volume       = {7},
      number       = {232},
      issn         = {1662-5161},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2013-02664},
      pages        = {1-17},
      year         = {2013},
      abstract     = {While the human medial prefrontal cortex (mPFC) is widely
                      believed to be a key node of neural networks relevant for
                      socio-emotional processing, its functional subspecialization
                      is still poorly understood. We thus revisited the often
                      assumed differentiation of the mPFC in social cognition
                      along its ventral-dorsal axis. Our neuroinformatic analysis
                      was based on a neuroimaging meta-analysis of
                      perspective-taking that yielded two separate clusters in the
                      ventral and dorsal mPFC, respectively. We determined each
                      seed region's brain-wide interaction pattern by two
                      complementary measures of functional connectivity:
                      co-activation across a wide range of neuroimaging studies
                      archived in the BrainMap database and correlated signal
                      fluctuations during unconstrained (“resting”) cognition.
                      Furthermore, we characterized the functions associated with
                      these two regions using the BrainMap database. Across
                      methods, the ventral mPFC was more strongly connected with
                      the nucleus accumbens, hippocampus, posterior cingulate
                      cortex, and retrosplenial cortex, while the dorsal mPFC was
                      more strongly connected with the inferior frontal gyrus,
                      temporo-parietal junction, and middle temporal gyrus.
                      Further, the ventral mPFC was selectively associated with
                      reward related tasks, while the dorsal mPFC was selectively
                      associated with perspective-taking and episodic memory
                      retrieval. The ventral mPFC is therefore predominantly
                      involved in bottom-up-driven, approach/avoidance-modulating,
                      and evaluation-related processing, whereas the dorsal mPFC
                      is predominantly involved in top–down-driven,
                      probabilistic-scene-informed, and metacognition-related
                      processing in social cognition.},
      cin          = {INM-1 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / HASB - Helmholtz Alliance
                      on Systems Biology (HGF-SystemsBiology)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-Juel1)HGF-SystemsBiology},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000319862700001},
      pubmed       = {pmid:23755001},
      doi          = {10.3389/fnhum.2013.00232},
      url          = {https://juser.fz-juelich.de/record/134490},
}