TY  - JOUR
AU  - Galldiks, Norbert
AU  - Rapp, Marion
AU  - Stoffels, Gabriele
AU  - Dunkl, Veronika
AU  - Sabel, Michael
AU  - Langen, Karl-Josef
TI  - Earlier Diagnosis of Progressive Disease during Bevacizumab Treatment Using O-(2-18F-Fluorethyl)-L-tyrosine Positron Emission Tomography in Comparison with Magnetic Resonance Imaging.
JO  - Molecular imaging
VL  - 12
IS  - 5
SN  - 1535-3508
CY  - Hamilton, Ont.
PB  - Decker
M1  - FZJ-2013-02822
SP  - 273-276
PY  - 2013
AB  - AbstractAntiangiogenic treatment using bevacizumab in brain tumor patients may cause difficulties in the diagnosis of tumor progression (ie, nonenhancing tumor progression). Newly defined criteria for treatment assessment and diagnosis of tumor progression (ie, RANO [Response Assessment in Neuro-Oncology] criteria) have implemented signal alterations on T2/fluid-attenuated inversion recovery (FLAIR) sequences to changes in contrast enhancement. However, T2/FLAIR hyperintensity may be influenced by other causes (eg, radiation-induced leukoencephalopathy, peritumoral edema, gliosis). Positron emission tomography using the radiolabeled amino acid O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET-PET) may help detect the metabolically active tumor extent. We present 18F-FET-PET imaging findings in a glioblastoma patient during bevacizumab treatment suggesting an earlier diagnosis of tumor progression than magnetic resonance imaging changes, which are based on the RANO criteria.
LB  - PUB:(DE-HGF)16
C6  - pmid:23759368
UR  - <Go to ISI:>//WOS:000336724400005
DO  - DOI:10.2310/7290.2013.00051
UR  - https://juser.fz-juelich.de/record/134725
ER  -