TY  - JOUR
AU  - Förster, M.
AU  - Laabs, V.
AU  - Lamshöft, M.
AU  - Pütz, T.
AU  - Amerlung, W.
TI  - Analysis of aged sulfadiazine residues in soils using microwave extraction and liquid  chromatagraphy tandem mass spectrometry
JO  - Analytical and bioanalytical chemistry
VL  - 391
SN  - 1618-2642
CY  - Berlin
PB  - Springer
M1  - PreJuSER-1353
SP  - 1029 - 1038
PY  - 2008
N1  - Record converted from VDB: 12.11.2012
AB  - An efficient extraction of sulfadiazine residues from soils is difficult, as sulfadiazine is known to form quickly sequestering residues. The objective of this study was to optimize an exhaustive extraction for aged residues of sulfadiazine and its two major metabolites, N-acetylsulfadiazine and 4-hydroxysulfadiazine, from soil. For this purpose two representative used agricultural soils (Luvisol, Cambisol) were blended with manure derived from [(14)C]sulfadiazine-treated pigs and incubated at 10 degrees C in the laboratory. After different extraction tests with various solvent mixtures (two- to four-component mixtures with water, methanol, acetonitrile, acetone, and/or ethyl acetate), different pH values (pH 4 and 9), and extraction temperatures (up to 200 degrees C), soil extracts were measured by liquid scintillation counting and liquid chromatography coupled to tandem mass spectrometry. With respect to sulfadiazine yields, stability of soil extracts, and the amount of coextracted matrix, a microwave extraction of soil (15 min, 150 degrees C) using acetonitrile/water 1:4 (v/v) is the method of choice for the exhaustive extraction of aged sulfadiazine residues from soils.
KW  - Chromatography, High Pressure Liquid: methods
KW  - Microwaves
KW  - Reproducibility of Results
KW  - Soil: analysis
KW  - Solid Phase Extraction: methods
KW  - Sulfadiazine: analysis
KW  - Sulfadiazine: radiation effects
KW  - Tandem Mass Spectrometry: methods
KW  - Soil (NLM Chemicals)
KW  - Sulfadiazine (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:18414833
UR  - <Go to ISI:>//WOS:000255996900040
DO  - DOI:10.1007/s00216-008-2081-1
UR  - https://juser.fz-juelich.de/record/1353
ER  -