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@ARTICLE{Boy:136190,
      author       = {Boy, Christian and Klimke, Ansgar and Holschbach, Markus
                      and Herzog, Hans and Mühlensiepen, Heinz and Rota Kops,
                      Elena and Sonnenberg, Frank and Gaebel, Wolfgang and
                      Stöcklin, Gerhard and Markstein, Rudolf and
                      Müller-Gärtner, Hans-W.},
      title        = {{I}maging {D}opamine {D}4 {R}eceptors in the {L}iving
                      {P}rimate {B}rain: {A} {P}ositron {E}mission {T}omography
                      {S}tudy {U}sing the {N}ovel {D}1/{D}4 {A}ntagonist
                      [11{C}]{SDZ} {GLC} 756},
      journal      = {Synapse},
      volume       = {30},
      publisher    = {Wiley},
      reportid     = {PreJuSER-136190},
      pages        = {341–350},
      note         = {Record converted from JUWEL: 18.07.2013},
      comment      = {Synapse 30:341–350},
      booktitle     = {Synapse 30:341–350},
      abstract     = {The dopamine D4 receptor has lately attracted interest
                      since it has been hypothesized to be involved in the
                      pathogenesis and pharmacotherapy of neuropsychiatric
                      diseases. The present study provides first in vivo evidence
                      of dopamine D4 receptors in primate brain using a
                      [11C]benzo[g]quinoline, the novel radioligand [11C]SDZ GLC
                      756 ([11C]GLC: in vitro dissociation constants at human
                      receptor clones [nM]: 1.10 at D1; 0.40 at D2; 25 at D3; 0.18
                      at D4.2; 6.03 at D5). Dynamic positron emission tomography
                      scans were performed on healthy baboons (Papio hamadryas, n
                      5 3). Specific receptor binding (SB) was calculated for
                      striatum and neocortex (frontal, temporal, parietal, and
                      occipital) based on the differences between the regional and
                      the cerebellar concentration of [11C]. Blockade of D1 and D5
                      receptors by SCH23390 (1.7 μmol/kg) diminished SB in the
                      striatum by 55 6 $4\%$ (mean 6 standard deviation, P , 0.05)
                      and in the frontal cortex by 13 6 $8\%$ (P , 0.05) when
                      compared to SB in the unblocked state (SBD1–D5). In the
                      presence of the dopamine antagonists SCH23390 (1.7 μmol/kg)
                      and raclopride (5.7 μmol/kg)—which mask the D1, D2, D3,
                      and D5 subtypes—SB of [11C]GLC to D4 receptors (SBD4) was
                      demonstrated in the striatum and all cortical regions of
                      interest. In the striatum, the ratio of SBD4/SBD1–D5 was
                      0.13 6 0.07. In the neocortex, SBD4/SBD1–D5 was notably
                      higher (0.77 60.29; mean of all cortical regions of
                      interest). The widespread distribution of dopamine D4
                      receptors suggests a basic functional role of this receptor
                      subtype in the modulation of cortical and subcortical
                      neuronal activity},
      cin          = {INM-4},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-4-20090406},
      typ          = {PUB:(DE-HGF)16},
      url          = {https://juser.fz-juelich.de/record/136190},
}