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@ARTICLE{Krause:136201,
author = {Krause, B. J. and Horwitz, B. and Taylor, J. G. and
Schmidt, D. and Mottaghy, F. M. and Herzog, H. and Halsband,
U. and Müller-Gärtner, H. -W.},
title = {{N}etwork analysis in episodic encoding and retrieval of
word-pair associates: a {PET} study},
journal = {European journal of neuroscience},
volume = {11},
publisher = {Wiley-Blackwell},
reportid = {PreJuSER-136201},
pages = {3293 - 3301},
note = {Record converted from JUWEL: 18.07.2013},
abstract = {The involvement of distributed brain regions in declarative
memory has been hypothesized based on studies with verbal
memory tasks. To characterize episodic declarative memory
function further, 14 right-handed volunteers performed a
visual verbal learning task using paired word associates.
The volunteers underwent positron emission tomography.
15O-butanol was used as a tracer of regional cerebral blood
flow (rCBF). Inter-regional functional interactions were
assessed based on within-task, across-subject interregional
rCBF correlations. Anatomical connections between brain
areas were based on known anatomy. Structural equation
modelling was used to calculate the path coefficients
representing the magnitudes of the functional influences of
each area on the ones to which it is connected by anatomical
pathways. The encoding and the retrieval network elicit
similarities in a general manner but also differences.
Strong functional linkages involving visual integration
areas, parahippocampal regions, left precuneus and cingulate
gyrus were found in both encoding and retrieval; the
functional linkages between posterior regions and prefrontal
regions were more closely linked during encoding, whereas
functional linkages between the left parahippocampal region
and posterior cingulate as well as extrastriate areas and
posterior cingulate gyrus were stronger during retrieval. In
conclusion, these findings support the idea of a global
bihemispheric, asymmetric encoding/retrieval network
subserving episodic declarative memory. Our results further
underline the role of the precuneus in episodic memory, not
only during retrieval but also during encoding.},
keywords = {episodic memory / network analysis / paired word associates
/ positron emission tomography / structural equation
modelling},
cin = {INM-4},
ddc = {500},
cid = {I:(DE-Juel1)INM-4-20090406},
typ = {PUB:(DE-HGF)16},
url = {https://juser.fz-juelich.de/record/136201},
}