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@ARTICLE{Mottaghy:136205,
author = {Mottaghy, F. M. and Shah, N. J. and Krause, B. J. and
Schmidt, D. and Halsband, U. and Jäncke, L. and
Müller-Gärtner, H. -W.},
title = {{N}euronal correlates of encoding and retrieval in episodic
memory during a paired-word association learning task: a
functional magnetic resonance imaging study},
journal = {Experimental brain research},
volume = {128},
issn = {0014-4819},
publisher = {Springer},
reportid = {PreJuSER-136205},
pages = {332 - 342},
note = {Record converted from JUWEL: 18.07.2013},
abstract = {The investigation of memory function using functional
magnetic resonance imaging (fMRI) is an expanding field of
research. The aim of this study was to demonstrate
brain-activity patterns related to a word-pair association
task employing a whole-brain EPI sequence. Six right-handed,
healthy male volunteers (mean age: 27.5 years) took part in
the study. fMRI was performed at a field strength of 1.5
Tesla with 26–32 slices parallel to the AC-PC line,
depending on individual brain size. Distributed brain
regions were activated in episodic encoding and retrieval
with similarities, but also (distinct) differences in
activation patterns. Bilateral prefrontal cortical areas
were involved when comparing encoding as well as retrieval
to the reference condition (nonsense words). Furthermore,
activation was observed in cerebellar areas during encoding,
and activation in bilateral parietal areas (precuneus and
inferior parietal cortex) was differentially more pronounced
during retrieval. The activation of left dorsomedial
thalamus during retrieval of high imagery-content word-pair
associates may point to the role of this structure in
episodic retrieval. The direct cognitive subtraction of
encoding minus retrieval yielded a differentially larger
left prefrontal activation. There was a differentially
higher right prefrontal activation during retrieval than
during encoding, underlining the proposed right/left
asymmetry for episodic memory processes.},
keywords = {Episodic memory / Paired word association / fMRI},
cin = {INM-4},
ddc = {500},
cid = {I:(DE-Juel1)INM-4-20090406},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000082947200007},
doi = {10.1007/s002210050853},
url = {https://juser.fz-juelich.de/record/136205},
}