% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Qin:13714,
      author       = {Qin, Z. and Caruso, J.A. and Lai, B. and Matusch, A. and
                      Becker, J.S.},
      title        = {{T}race metal imaging with high spatial resolution:
                      {A}pplications in biomedicine},
      journal      = {Metallomics},
      volume       = {3},
      issn         = {1756-5901},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {PreJuSER-13714},
      pages        = {28 - 37},
      year         = {2011},
      note         = {This work was supported by an AHA National Scientist
                      Development Grant (0835268N).},
      abstract     = {New generations of analytical techniques for imaging of
                      metals are pushing hitherto boundaries of spatial resolution
                      and quantitative analysis in biology. Because of this, the
                      application of these imaging techniques described herein to
                      the study of the organization and dynamics of metal cations
                      and metal-containing biomolecules in biological cell and
                      tissue is becoming an important issue in biomedical
                      research. In the current review, three common metal imaging
                      techniques in biomedical research are introduced, including
                      synchrotron X-ray fluorescence (SXRF) microscopy, secondary
                      ion mass spectrometry (SIMS), and laser ablation inductively
                      coupled plasma mass spectrometry (LA-ICP-MS). These are
                      exemplified by a demonstration of the dopamine-Fe complexes,
                      by assessment of boron distribution in a boron neutron
                      capture therapy cell model, by mapping Cu and Zn in human
                      brain cancer and a rat brain tumor model, and by the
                      analysis of metal topography within neuromelanin. These
                      studies have provided solid evidence that demonstrates that
                      the sensitivity, spatial resolution, specificity, and
                      quantification ability of metal imaging techniques is
                      suitable and highly desirable for biomedical research.
                      Moreover, these novel studies on the nanometre scale (e.g.,
                      of individual single cells or cell organelles) will lead to
                      a better understanding of metal processes in cells and
                      tissues.},
      keywords     = {Animals / Biomedical Technology: methods / Brain: cytology
                      / Brain: metabolism / Brain: pathology / Copper: analysis /
                      Copper: chemistry / Cytological Techniques: methods /
                      Glioblastoma: metabolism / Glioblastoma: pathology / Humans
                      / Mass Spectrometry / Molecular Imaging: methods / Rats /
                      Spectrometry, X-Ray Emission / Zinc: analysis / Zinc:
                      chemistry / Copper (NLM Chemicals) / Zinc (NLM Chemicals) /
                      J (WoSType)},
      cin          = {ZCH / INM-2},
      ddc          = {690},
      cid          = {I:(DE-Juel1)ZCH-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Biochemistry $\&$ Molecular Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21140012},
      UT           = {WOS:000286057100002},
      doi          = {10.1039/c0mt00048e},
      url          = {https://juser.fz-juelich.de/record/13714},
}