TY  - JOUR
AU  - Bannach, O.
AU  - Reinartz, E.
AU  - Henke, F.
AU  - Dreßen, F.
AU  - Oelschlegel, A.
AU  - Kaatz, M.
AU  - Groschup, M. H.
AU  - Willbold, D.
AU  - Riesner, D.
AU  - Birkmann, E.
TI  - Analysis of prion protein aggregates in blood and brain from pre-clinical and clinical BSE cases
JO  - Veterinary microbiology
VL  - 166
IS  - 1-2
SN  - 0378-1135
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2013-03735
SP  - 102 - 108
PY  - 2013
AB  - Prion diseases are infectious neurodegenerative diseases affecting humans and animals. The food-borne bovine spongiform encephalopathy (BSE) had serious impact on both economy and public health, respectively. To follow the pathogenesis of BSE, oral challenge studies were previously conducted, among others on the Isle of Riems, Germany (Balkema-Buschmann et al., 2011b). In the present work brain and plasma samples from this pathogenesis study were subjected to surface fluorescence distribution analysis (sFIDA). sFIDA is a diagnostic tool that exploits the aggregated state of the disease-related prion protein (PrP) as a biomarker for prion disorders.
AB  - 
AB  - With the exception of one animal, all tested brain samples from clinical cattle exhibited a high titer of PrP particles. Moreover we could detect PrP aggregates already 16 and 24 months after infection. In contrast to our previous demonstration of PrP particles in blood plasma from scrapie sheep, however, no aggregates could be identified in plasma from pre-clinical and clinical cattle. This is in accordance with other studies suggesting a restriction of the BSE infection to the central nervous system.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000322848100011
C6  - pmid:23845735
DO  - DOI:10.1016/j.vetmic.2013.05.021
UR  - https://juser.fz-juelich.de/record/137278
ER  -