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@ARTICLE{Bannach:137278,
      author       = {Bannach, O. and Reinartz, E. and Henke, F. and Dreßen, F.
                      and Oelschlegel, A. and Kaatz, M. and Groschup, M. H. and
                      Willbold, D. and Riesner, D. and Birkmann, E.},
      title        = {{A}nalysis of prion protein aggregates in blood and brain
                      from pre-clinical and clinical {BSE} cases},
      journal      = {Veterinary microbiology},
      volume       = {166},
      number       = {1-2},
      issn         = {0378-1135},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2013-03735},
      pages        = {102 - 108},
      year         = {2013},
      abstract     = {Prion diseases are infectious neurodegenerative diseases
                      affecting humans and animals. The food-borne bovine
                      spongiform encephalopathy (BSE) had serious impact on both
                      economy and public health, respectively. To follow the
                      pathogenesis of BSE, oral challenge studies were previously
                      conducted, among others on the Isle of Riems, Germany
                      (Balkema-Buschmann et al., 2011b). In the present work brain
                      and plasma samples from this pathogenesis study were
                      subjected to surface fluorescence distribution analysis
                      (sFIDA). sFIDA is a diagnostic tool that exploits the
                      aggregated state of the disease-related prion protein (PrP)
                      as a biomarker for prion disorders. With the exception of
                      one animal, all tested brain samples from clinical cattle
                      exhibited a high titer of PrP particles. Moreover we could
                      detect PrP aggregates already 16 and 24 months after
                      infection. In contrast to our previous demonstration of PrP
                      particles in blood plasma from scrapie sheep, however, no
                      aggregates could be identified in plasma from pre-clinical
                      and clinical cattle. This is in accordance with other
                      studies suggesting a restriction of the BSE infection to the
                      central nervous system.},
      cin          = {ICS-6},
      ddc          = {630},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000322848100011},
      pubmed       = {pmid:23845735},
      doi          = {10.1016/j.vetmic.2013.05.021},
      url          = {https://juser.fz-juelich.de/record/137278},
}