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000137555 0247_ $$2DOI$$a10.2310/7290.2013.00056
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000137555 037__ $$aFZJ-2013-03987
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000137555 1001_ $$0P:(DE-HGF)0$$aPiroth, Marc D$$b0$$eCorresponding author
000137555 245__ $$aMonitoring of Radiochemotherapy in Patients with Glioblastoma Using O-(2-[18F]Fluoroethyl)-L-Tyrosine Positron Emission Tomography: Is Dynamic Imaging Helpful?
000137555 260__ $$aHamilton, Ont.$$bDecker$$c2013
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000137555 520__ $$aMonitoring of radiochemotherapy (RCX) in patients with glioblastoma is difficult because unspecific alterations in magnetic resonance imaging with contrast enhancement can mimic tumor progression. Changes in tumor to brain ratios (TBRs) in positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) after RCX with temozolomide of patients with glioblastoma have been shown to be valuable parameters to predict survival. The kinetic behavior of 18F-FET in the tumors is another promising parameter to analyze tumor metabolism. In this study, we investigated the predictive value of dynamic 18F-FET PET during RCX of glioblastoma. Time-activity curves (TACs) of 18F-FET uptake of 25 patients with glioblastoma were evaluated after surgery (FET-1), early (7-10 days) after completion of RCX (FET-2), and 6 to 8 weeks later (FET-3). Changes in the time to peak (TTP) and the slope of the TAC (10-50 minutes postinjection) were analyzed and related to survival. Changes in kinetic parameters of 18F-FET uptake after RCX showed no relationship with survival time. In contrast, the high predictive value of changes of TBR to predict survival was confirmed. We conclude that dynamic 18F-FET PET does not provide additional prognostic information during RCX. Static 18F-FET PET imaging (20-40 minutes postinjection) appears to be sufficient for this purpose and reduces costs.
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000137555 7001_ $$0P:(DE-HGF)0$$aLiebenstund, Sarah$$b1
000137555 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b2$$ufzj
000137555 7001_ $$0P:(DE-Juel1)131627$$aStoffels, Gabriele$$b3$$ufzj
000137555 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b4$$ufzj
000137555 7001_ $$0P:(DE-HGF)0$$aEble, Michael J$$b5
000137555 7001_ $$0P:(DE-Juel1)131816$$aCoenen, Heinrich Hubert$$b6$$ufzj
000137555 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b7$$ufzj
000137555 773__ $$0PERI:(DE-600)2069848-3$$gVol. 12, no. 6$$n6$$p388-395$$tMolecular imaging$$v12$$x1535-3508$$y2013
000137555 8564_ $$zPublished final document.
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