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@ARTICLE{Piroth:137555,
      author       = {Piroth, Marc D and Liebenstund, Sarah and Galldiks, Norbert
                      and Stoffels, Gabriele and Shah, N. J. and Eble, Michael J
                      and Coenen, Heinrich Hubert and Langen, Karl-Josef},
      title        = {{M}onitoring of {R}adiochemotherapy in {P}atients with
                      {G}lioblastoma {U}sing
                      {O}-(2-[18{F}]{F}luoroethyl)-{L}-{T}yrosine {P}ositron
                      {E}mission {T}omography: {I}s {D}ynamic {I}maging
                      {H}elpful?},
      journal      = {Molecular imaging},
      volume       = {12},
      number       = {6},
      issn         = {1535-3508},
      address      = {Hamilton, Ont.},
      publisher    = {Decker},
      reportid     = {FZJ-2013-03987},
      pages        = {388-395},
      year         = {2013},
      abstract     = {Monitoring of radiochemotherapy (RCX) in patients with
                      glioblastoma is difficult because unspecific alterations in
                      magnetic resonance imaging with contrast enhancement can
                      mimic tumor progression. Changes in tumor to brain ratios
                      (TBRs) in positron emission tomography (PET) using
                      O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) after RCX with
                      temozolomide of patients with glioblastoma have been shown
                      to be valuable parameters to predict survival. The kinetic
                      behavior of 18F-FET in the tumors is another promising
                      parameter to analyze tumor metabolism. In this study, we
                      investigated the predictive value of dynamic 18F-FET PET
                      during RCX of glioblastoma. Time-activity curves (TACs) of
                      18F-FET uptake of 25 patients with glioblastoma were
                      evaluated after surgery (FET-1), early (7-10 days) after
                      completion of RCX (FET-2), and 6 to 8 weeks later (FET-3).
                      Changes in the time to peak (TTP) and the slope of the TAC
                      (10-50 minutes postinjection) were analyzed and related to
                      survival. Changes in kinetic parameters of 18F-FET uptake
                      after RCX showed no relationship with survival time. In
                      contrast, the high predictive value of changes of TBR to
                      predict survival was confirmed. We conclude that dynamic
                      18F-FET PET does not provide additional prognostic
                      information during RCX. Static 18F-FET PET imaging (20-40
                      minutes postinjection) appears to be sufficient for this
                      purpose and reduces costs.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {332 - Imaging the Living Brain (POF2-332)},
      pid          = {G:(DE-HGF)POF2-332},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23981784},
      UT           = {WOS:000336725000001},
      doi          = {10.2310/7290.2013.00056},
      url          = {https://juser.fz-juelich.de/record/137555},
}