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@ARTICLE{Jacobs:137669,
      author       = {Jacobs, Heidi and Gronenschild, E. H. B. M. and Evers, E.
                      A. T. and Ramakers, I. H. G. B. and Hofman, P. A. M. and
                      Backes, W. H. and Jolles, J. and Verhey, F. R. J. and van
                      Boxtel, M. P. J.},
      title        = {{V}isuospatial processing in early {A}lzheimer’s disease:
                      a multimodal neuroimaging study},
      journal      = {Cortex},
      volume       = {64},
      issn         = {0010-9452},
      address      = {Paris},
      publisher    = {Elsevier Masson},
      reportid     = {FZJ-2013-04015},
      pages        = {394 - 406},
      year         = {2015},
      abstract     = {IntroductionDorsal pathway dysfunctions are thought to
                      underlie visuospatial processing problems in Alzheimer
                      disease (AD). Prior studies reported compensatory mechanisms
                      in the dorsal or ventral pathway in response to these
                      functional changes. Since functional and structural
                      connectivity are interrelated, these functional changes
                      could be interpreted as a disconnection between both
                      pathways. To better understand functional alterations in the
                      dorsal pathway, we combined functional imaging with
                      diffusion tensor imaging (DTI) in patients with mild
                      cognitive impairment (MCI), a likely prodromal stage of
                      AD.MethodsEighteen older male individuals with amnestic MCI
                      (aMCI) and 18 male cognitively healthy individuals, matched
                      for age (range 59–75 years) and education, performed an
                      object recognition task in the Magnetic Resonance Imaging
                      (MRI) scanner. Neural activation was measured during
                      recognition of non-canonically versus canonically oriented
                      objects. Regions showing activation differences between
                      groups were also investigated by DTI.ResultsRecognition of
                      non-canonical objects elicited increased frontal, temporal
                      and parietal activation. Combining the functional MRI (fMRI)
                      with the DTI results showed less deactivation in areas with
                      decreased diffusion (mediolateral parietal and
                      orbitofrontal) and increased activation in areas with
                      increased diffusion (parietal and temporal) in aMCI
                      patients. Finally, in aMCI patients decreased diffusion was
                      found in the hippocampal cingulum, connecting both
                      pathways.ConclusionsOur results showed increased activation
                      in early AD patients in ventral and dorsal pathways. A
                      decrease in deactivation and diffusion suggests functional
                      reorganization, while increased activation and diffusion
                      suggests compensatory processes. This is the first study
                      showing structural evidence for functional reorganization,
                      which may be related to connectivity loss in the cingulum.},
      cin          = {INM-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000351248400036},
      doi          = {10.1016/j.cortex.2012.01.005},
      url          = {https://juser.fz-juelich.de/record/137669},
}