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@ARTICLE{Sturm:137679,
      author       = {Sturm, Walter and Thimm, M. and Binkofski, F. and
                      Horoufchin, H. and Fink, G. R. and Küst, J. and Karbe, H.
                      and Willmes, K.},
      title        = {{C}ombined {S}pace and {A}lertness {R}elated {T}herapy of
                      {V}isual {H}emineglect: {E}ffect of {T}herapy {F}requency},
      journal      = {Frontiers in human neuroscience},
      volume       = {7},
      number       = {373},
      issn         = {1662-5161},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2013-04025},
      pages        = {1-12},
      year         = {2013},
      abstract     = {The combined efficacy of space- and alertness related
                      training in chronic hemineglect was tested behaviorally and
                      in a longitudinal fMRI study. Earlier results had shown that
                      both space as well as alertness related training as single
                      intervention methods lead to short term improvement which,
                      however, is not stable for longer time periods. The
                      neurobiological data obtained in these studies revealed
                      differential cortical reorganization patterns for the two
                      training approaches thereby leading to the hypothesis that a
                      combination of both trainings might result in stronger and
                      longer lasting effects. The results of our current study,
                      however, – at least at first glance – do not clearly
                      corroborate this hypothesis, because neither alertness
                      training alone nor the combination with OKS on the group
                      level led to significant behavioral improvement, although
                      four of the six patients after alertness and even more after
                      combined training showed a higher percentage of behavioral
                      improvement than during baseline. Despite the lack of
                      clearcut behavioral training induced improvement we found
                      right parietal or fronto-parietal increase of activation in
                      the imaging data immediately after combined training and at
                      follow-up 3 weeks later. The study design had called for
                      splitting up training time between the two training
                      approaches in order to match total training time with our
                      earlier single training studies. The results of our current
                      study are discussed as a possible consequence of reduced
                      training time and intensity of both training measures under
                      the combined training situation.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 89572 - (Dys-)function and
                      Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000322435600001},
      UT           = {WOS:000322435600001},
      pubmed       = {pmid:23908613},
      doi          = {10.3389/fnhum.2013.00373},
      url          = {https://juser.fz-juelich.de/record/137679},
}