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@ARTICLE{Feldmeyer:137776,
      author       = {Feldmeyer, Dirk and Brecht, Michael and Helmchen, Fritjof
                      and Petersen, Carl C. H. and Poulet, James F. A. and
                      Staiger, Jochen F. and Luhmann, Heiko J. and Schwarz,
                      Cornelius},
      title        = {{B}arrel cortex function},
      journal      = {Progress in neurobiology},
      volume       = {103},
      issn         = {0301-0082},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2013-04092},
      pages        = {3 - 27},
      year         = {2013},
      abstract     = {Neocortex, the neuronal structure at the base of the
                      remarkable cognitive skills of mammals, is a layered sheet
                      of neuronal tissue composed of juxtaposed and interconnected
                      columns. A cortical column is considered the basic module of
                      cortical processing present in all cortical areas. It is
                      believed to contain a characteristic microcircuit composed
                      of a few thousand neurons. The high degree of cortical
                      segmentation into vertical columns and horizontal layers is
                      a boon for scientific investigation because it eases the
                      systematic dissection and functional analysis of intrinsic
                      as well as extrinsic connections of the column. In this
                      review we will argue that in order to understand neocortical
                      function one needs to combine a microscopic view,
                      elucidating the workings of the local columnar
                      microcircuits, with a macroscopic view, which keeps track of
                      the linkage of distant cortical modules in different
                      behavioral contexts. We will exemplify this strategy using
                      the model system of vibrissal touch in mice and rats. On the
                      macroscopic level vibrissal touch is an important sense for
                      the subterranean rodents and has been honed by evolution to
                      serve an array of distinct behaviors. Importantly, the
                      vibrissae are moved actively to touch - requiring intricate
                      sensorimotor interactions. Vibrissal touch, therefore,
                      offers ample opportunities to relate different behavioral
                      contexts to specific interactions of distant columns. On the
                      microscopic level, the cortical modules in primary
                      somatosensory cortex process touch inputs at highest
                      magnification and discreteness - each whisker is represented
                      by its own so-called barrel column. The cellular
                      composition, intrinsic connectivity and functional aspects
                      of the barrel column have been studied in great detail.
                      Building on the versatility of genetic tools available in
                      rodents, new, highly selective and flexible cellular and
                      molecular tools to monitor and manipulate neuronal activity
                      have been devised. Researchers have started to combine these
                      with advanced and highly precise behavioral methods, on par
                      with the precision known from monkey preparations.
                      Therefore, the vibrissal touch model system is exquisitely
                      positioned to combine the microscopic with the macroscopic
                      view and promises to be instrumental in our understanding of
                      neocortical function.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {331 - Signalling Pathways and Mechanisms in the Nervous
                      System (POF2-331)},
      pid          = {G:(DE-HGF)POF2-331},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000318321400002},
      pubmed       = {pmid:23195880},
      doi          = {10.1016/j.pneurobio.2012.11.002},
      url          = {https://juser.fz-juelich.de/record/137776},
}