000137828 001__ 137828
000137828 005__ 20210129212117.0
000137828 0247_ $$2doi$$a10.1016/j.nucmedbio.2013.09.001
000137828 0247_ $$2WOS$$aWOS:000328009300001
000137828 037__ $$aFZJ-2013-04138
000137828 082__ $$a610
000137828 1001_ $$0P:(DE-Juel1)131691$$aKroll, Tina$$b0$$eCorresponding author$$ufzj
000137828 245__ $$a[18F]Altanserin and small animal PET: Impact of multidrug efflux transporters on ligand brain uptake and subsequent quantification of 5-HT2A receptor densities in the rat brain
000137828 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2014
000137828 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1392903127_23713
000137828 3367_ $$2DataCite$$aOutput Types/Journal article
000137828 3367_ $$00$$2EndNote$$aJournal Article
000137828 3367_ $$2BibTeX$$aARTICLE
000137828 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000137828 3367_ $$2DRIVER$$aarticle
000137828 500__ $$3POF3_Assignment on 2016-02-29
000137828 520__ $$aThe selective 5-hydroxytryptamine type 2a receptor (5-HT2AR) radiotracer [18F]altanserin is a promising ligand for in vivo brain imaging in rodents. However, [18F]altanserin is a substrate of P-glycoprotein (P-gp) in rats. Its applicability might therefore be constrained by both a differential expression of P-gp under pathological conditions, e.g. epilepsy, and its relatively low cerebral uptake. The aim of the present study was therefore twofold: (i) to investigate whether inhibition of multidrug transporters (MDT) is suitable to enhance the cerebral uptake of [18F]altanserin in vivo and (ii) to test different pharmacokinetic, particularly reference tissue-based models for exact quantification of 5-HT2AR densities in the rat brain.
000137828 536__ $$0G:(DE-HGF)POF2-333$$a333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333)$$cPOF2-333$$fPOF II$$x0
000137828 7001_ $$0P:(DE-Juel1)138474$$aMatusch, Andreas$$b1$$ufzj
000137828 7001_ $$0P:(DE-Juel1)131756$$aCelik, A. Avdo$$b2$$ufzj
000137828 7001_ $$0P:(DE-Juel1)131711$$aWedekind, Franziska$$b3$$ufzj
000137828 7001_ $$0P:(DE-Juel1)131712$$aWeißhaupt, Angela$$b4$$ufzj
000137828 7001_ $$0P:(DE-Juel1)133864$$aBeer, Simone$$b5$$ufzj
000137828 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b6$$ufzj
000137828 773__ $$0PERI:(DE-600)1498538-x$$a10.1016/j.nucmedbio.2013.09.001$$n1$$p1-9$$tNuclear medicine and biology$$v41$$x1872-9614
000137828 8564_ $$uhttps://juser.fz-juelich.de/record/137828/files/FZJ-2013-04138.pdf$$yRestricted$$zPublished final document.
000137828 909CO $$ooai:juser.fz-juelich.de:137828$$pVDB
000137828 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131691$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
000137828 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)138474$$aForschungszentrum Jülich GmbH$$b1$$kFZJ
000137828 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131756$$aForschungszentrum Jülich GmbH$$b2$$kFZJ
000137828 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131711$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000137828 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131712$$aForschungszentrum Jülich GmbH$$b4$$kFZJ
000137828 9101_ $$0I:(DE-Juel1)ZEA-2-20090406$$6P:(DE-Juel1)133864$$aZentralinstitut für Elektronik$$b5$$kZEA-2
000137828 9101_ $$0I:(DE-Juel1)INM-2-20090406$$6P:(DE-Juel1)133864$$aMolekulare Organisation des Gehirns$$b5$$kINM-2
000137828 9101_ $$0I:(DE-Juel1)ZEA-2-20090406$$6P:(DE-Juel1)133864$$aZentralinstitut für Elektronik$$b5$$kZEA-2
000137828 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)133864$$aForschungszentrum Jülich GmbH$$b5$$kFZJ
000137828 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131672$$aForschungszentrum Jülich GmbH$$b6$$kFZJ
000137828 9132_ $$0G:(DE-HGF)POF3-579H$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vAddenda$$x0
000137828 9131_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000137828 9141_ $$y2014
000137828 915__ $$0StatID:(DE-HGF)0040$$2StatID$$aPeer review unknown
000137828 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000137828 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000137828 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000137828 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000137828 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000137828 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000137828 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000137828 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000137828 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000137828 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000137828 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000137828 9201_ $$0I:(DE-Juel1)INM-2-20090406$$kINM-2$$lMolekulare Organisation des Gehirns$$x0
000137828 9201_ $$0I:(DE-Juel1)INM-4-20090406$$kINM-4$$lPhysik der Medizinischen Bildgebung$$x1
000137828 980__ $$ajournal
000137828 980__ $$aVDB
000137828 980__ $$aUNRESTRICTED
000137828 980__ $$aI:(DE-Juel1)INM-2-20090406
000137828 980__ $$aI:(DE-Juel1)INM-4-20090406
000137828 981__ $$aI:(DE-Juel1)INM-4-20090406