% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kroll:137828,
      author       = {Kroll, Tina and Matusch, Andreas and Celik, A. Avdo and
                      Wedekind, Franziska and Weißhaupt, Angela and Beer, Simone
                      and Bauer, Andreas},
      title        = {[18{F}]{A}ltanserin and small animal {PET}: {I}mpact of
                      multidrug efflux transporters on ligand brain uptake and
                      subsequent quantification of 5-{HT}2{A} receptor densities
                      in the rat brain},
      journal      = {Nuclear medicine and biology},
      volume       = {41},
      number       = {1},
      issn         = {1872-9614},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2013-04138},
      pages        = {1-9},
      year         = {2014},
      abstract     = {The selective 5-hydroxytryptamine type 2a receptor
                      (5-HT2AR) radiotracer [18F]altanserin is a promising ligand
                      for in vivo brain imaging in rodents. However,
                      [18F]altanserin is a substrate of P-glycoprotein (P-gp) in
                      rats. Its applicability might therefore be constrained by
                      both a differential expression of P-gp under pathological
                      conditions, e.g. epilepsy, and its relatively low cerebral
                      uptake. The aim of the present study was therefore twofold:
                      (i) to investigate whether inhibition of multidrug
                      transporters (MDT) is suitable to enhance the cerebral
                      uptake of [18F]altanserin in vivo and (ii) to test different
                      pharmacokinetic, particularly reference tissue-based models
                      for exact quantification of 5-HT2AR densities in the rat
                      brain.},
      cin          = {INM-2 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000328009300001},
      doi          = {10.1016/j.nucmedbio.2013.09.001},
      url          = {https://juser.fz-juelich.de/record/137828},
}