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@ARTICLE{Qi:137875,
      author       = {Qi, Guanxiao and Feldmeyer, Dirk},
      title        = {{D}endritic {T}arget {R}egion-{S}pecific {F}ormation of
                      {S}ynapses {B}etween {E}xcitatory {L}ayer 4 {N}eurons and
                      {L}ayer 6 {P}yramidal {C}ells},
      journal      = {Cerebral cortex},
      volume       = {26},
      number       = {4},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2013-04185},
      pages        = {1569-1579},
      year         = {2016},
      abstract     = {Excitatory connections between neocortical layer 4 (L4) and
                      L6 are part of the corticothalamic feedback microcircuitry.
                      Here we studied the intracortical element of this feedback
                      loop, the L4 spiny neuron-to-L6 pyramidal cell connection.
                      We found that the distribution of synapses onto both
                      putative corticothalamic (CT) and corticocortical (CC) L6
                      pyramidal cells (PCs) depends on the presynaptic L4 neuron
                      type but is independent of the postsynaptic L6 PC type. L4
                      spiny stellate cells establish synapses on distal apical
                      tuft dendrites of L6 PCs and elicit slow unitary excitatory
                      postsynaptic potentials (uEPSPs) in L6 somata. In contrast,
                      the majority of L4 star pyramidal neurons target basal and
                      proximal apical oblique dendrites of L6 PCs and show fast
                      uEPSPs. Compartmental modeling suggests that the slow uEPSP
                      time course is primarily the result of dendritic filtering.
                      This suggests that the dendritic target specificity of the 2
                      L4 spiny neuron types is due to their different axonal
                      projection patterns across cortical layers. The preferential
                      dendritic targeting by different L4 neuron types may
                      facilitate the generation of dendritic Ca2+ or Na+ action
                      potentials in L6 PCs; this could play a role in synaptic
                      gain modulation in the corticothalamic pathway.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000374246700019},
      doi          = {10.1093/cercor/bhu334},
      url          = {https://juser.fz-juelich.de/record/137875},
}