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@ARTICLE{Unthan:138179,
      author       = {Unthan, Simon and Grünberger, Alexander and van Ooyen, Jan
                      and Gätgens, Jochem and Heinrich, Johanna and Paczia,
                      Nicole and Wiechert, Wolfgang and Kohlheyer, Dietrich and
                      Noack, Stephan},
      title        = {{B}eyond growth rate 0.6: {W}hat drives {C}orynebacterium
                      glutamicum to higher growth rates in defined medium},
      journal      = {Biotechnology $\&$ bioengineering},
      volume       = {111},
      number       = {2},
      issn         = {0006-3592},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2013-04404},
      pages        = {359–371},
      year         = {2014},
      abstract     = {In a former study we showed that Corynebacterium glutamicum
                      grows much faster in defined CGXII glucose medium when
                      growth was initiated in highly diluted environments
                      [Grünberger et al. (2013b) Biotechnol Bioeng]. Here we
                      studied the batch growth of C. glutamicum in CGXII at a
                      comparable low starting biomass concentration of
                      OD ≈ 0.005 in more detail. During bioreactor
                      cultivations a bi-phasic growth behavior with changing
                      growth rates was observed. Initially the culture grew with
                      inline image before the growth rate dropped to inline image.
                      We were able to confirm the elevated growth rate for C.
                      glutamicum in CGXII and showed for the first time a growth
                      rate beyond 0.6 in lab-scale bioreactor cultivations on
                      defined medium. Advanced growth studies combining
                      well-designed bioreactor and microfluidic single-cell
                      cultivations (MSCC) with quantitative transcriptomics,
                      metabolomics and integrative in silico analysis revealed
                      protocatechuic acid as a hidden co-substrate for accelerated
                      growth within CGXII. The presented approach proves the
                      general applicability of MSCC to investigate and validate
                      the effect of single medium components on microorganism
                      growth during cultivation in liquid media, and therefore
                      might be of interest for any kind of basic growth study},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {899 - ohne Topic (POF2-899)},
      pid          = {G:(DE-HGF)POF2-899},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000330969300014},
      doi          = {10.1002/bit.25103},
      url          = {https://juser.fz-juelich.de/record/138179},
}