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@ARTICLE{Yakushenko:138416,
      author       = {Yakushenko, Alexey and Kätelhön, Enno and Wolfrum,
                      Bernhard},
      title        = {{P}arallel {O}n-{C}hip {A}nalysis of {S}ingle {V}esicle
                      {N}eurotransmitter {R}elease},
      journal      = {Analytical chemistry},
      volume       = {85},
      number       = {11},
      issn         = {1520-6882},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {FZJ-2013-04547},
      pages        = {5483 - 5490},
      year         = {2013},
      abstract     = {Real-time investigations of neurotransmitter release
                      provide a direct insight on the mechanisms involved in
                      synaptic communication. Carbon fiber microelectrodes are
                      state-of-the-art tools for electrochemical measurements of
                      single vesicle neurotransmitter release. Yet, they lack
                      high-throughput capabilities that are required for
                      collecting robust statistically significant data across
                      multiple samples. Here, we present a chip-based recording
                      system enabling parallel in vitro measurements of individual
                      neurotransmitter release events from cells, cultured
                      directly on planar multielectrode arrays. The applicability
                      of this cell-based platform to pharmacological screening is
                      demonstrated by resolving minute concentration-dependent
                      effects of the dopamine reuptake inhibitor nomifensine on
                      recorded single-vesicle release events from PC12 cells. The
                      experimental results, showing an increased half-time of the
                      recorded events, are complemented by an analytical model for
                      the verification of drug action.},
      cin          = {ICS-8 / PGI-8 / JARA-FIT},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-8-20110106 / I:(DE-Juel1)PGI-8-20110106 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {423 - Sensorics and bioinspired systems (POF2-423) / 453 -
                      Physics of the Cell (POF2-453) / Helmholtz Young
                      Investigators Group (HGF-YoungInvestigatorsGroup)},
      pid          = {G:(DE-HGF)POF2-423 / G:(DE-HGF)POF2-453 /
                      G:(DE-HGF)HGF-YoungInvestigatorsGroup},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000320096900030},
      pubmed       = {pmid:23642073},
      doi          = {10.1021/ac4006183},
      url          = {https://juser.fz-juelich.de/record/138416},
}