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@ARTICLE{Yakushenko:138421,
      author       = {Yakushenko, Alexey and Gong, Zheng and Maybeck, Vanessa and
                      Hofmann, Boris and Gu, Erdan and Dawson, Martin and
                      Offenhäusser, Andreas and Wolfrum, Bernhard},
      title        = {{O}n-chip optical stimulation and electrical recording from
                      cells},
      journal      = {Journal of biomedical optics},
      volume       = {18},
      number       = {11},
      issn         = {1083-3668},
      address      = {Bellingham, Wash.},
      publisher    = {SPIE},
      reportid     = {FZJ-2013-04552},
      pages        = {111402},
      year         = {2013},
      abstract     = {We present an optoelectrical device capable of in vitro
                      optical stimulation and electrophysiological recording. The
                      device consists of an array of micropixellated InGaN
                      light-emitting diodes coupled to a custom-made ultrathin
                      planar microelectrode array. Cells can be cultured directly
                      on the chip for short- and long-term electrophysiological
                      experiments. To show the functionality of the device, we
                      transfected a cardiomyocyte-like cell line (HL-1) with a
                      light-sensitive protein channelrhodopsin. We monitored
                      action potentials of individual, spontaneously beating, HL-1
                      cells growing on the chip by extracellular electrical
                      recordings. On-chip optical stimulation was demonstrated by
                      triggering network activity in a confluent HL-1 cell culture
                      and visualized by calcium imaging. We see the potential of
                      our system for electrophysiological experiments with
                      optogenetically modified cells. Optical stimulation can be
                      performed directly on the chip without additional optical
                      components or external light sources.},
      cin          = {ICS-8 / PGI-8 / JARA-FIT},
      ddc          = {530},
      cid          = {I:(DE-Juel1)ICS-8-20110106 / I:(DE-Juel1)PGI-8-20110106 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {423 - Sensorics and bioinspired systems (POF2-423) / 453 -
                      Physics of the Cell (POF2-453) / Helmholtz Young
                      Investigators Group (HGF-YoungInvestigatorsGroup)},
      pid          = {G:(DE-HGF)POF2-423 / G:(DE-HGF)POF2-453 /
                      G:(DE-HGF)HGF-YoungInvestigatorsGroup},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000328895100007},
      pubmed       = {pmid:23788259},
      doi          = {10.1117/1.JBO.18.11.111402},
      url          = {https://juser.fz-juelich.de/record/138421},
}