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@ARTICLE{vanAerde:138509,
      author       = {van Aerde, K. I. and Qi, G. and Feldmeyer, D.},
      title        = {{C}ell {T}ype-{S}pecific {E}ffects of {A}denosine on
                      {C}ortical {N}eurons},
      journal      = {Cerebral cortex},
      volume       = {25},
      number       = {3},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2013-04618},
      pages        = {772-787},
      year         = {2015},
      abstract     = {The neuromodulator adenosine is widely considered to be a
                      key regulator of sleep homeostasis and an indicator of sleep
                      need. Although the effect of adenosine on subcortical areas
                      has been previously described, the effects on cortical
                      neurons have not been addressed systematically to date. To
                      that purpose, we performed in vitro whole-cell patch-clamp
                      recordings and biocytin staining of pyramidal neurons and
                      interneurons throughout all layers of rat prefrontal and
                      somatosensory cortex, followed by morphological analysis. We
                      found that adenosine, via the A1 receptor, exerts
                      differential effects depending on neuronal cell type and
                      laminar location. Interneurons and pyramidal neurons in
                      layer 2 and a subpopulation of layer 3 pyramidal neurons
                      that displayed regular spiking were insensitive to adenosine
                      application, whereas other pyramidal cells in layers 3–6
                      were hyperpolarized (range 1.2–10.8 mV). Broad tufted
                      pyramidal neurons with little spike adaptation showed a
                      small adenosine response, whereas slender tufted pyramidal
                      neurons with substantial adaptation showed a bigger
                      response. These studies of the action of adenosine at the
                      postsynaptic level may contribute to the understanding of
                      the changes in cortical circuit functioning that take place
                      between sleep and awakening.},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000351935800017},
      pubmed       = {pmid:24108800},
      doi          = {10.1093/cercor/bht274},
      url          = {https://juser.fz-juelich.de/record/138509},
}