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@ARTICLE{Yerabham:139115,
      author       = {Yerabham, Antony S. K. and Weiergräber, Oliver H. and
                      Bradshaw, Nicholas J. and Korth, Carsten},
      title        = {{R}evisiting {D}isrupted-in-{S}chizophrenia 1 as a scaffold
                      protein},
      journal      = {Biological chemistry},
      volume       = {394},
      number       = {11},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2013-05122},
      pages        = {1425-1437},
      year         = {2013},
      abstract     = {Disrupted-in-Schizophrenia 1 (DISC1) is a widely-accepted
                      genetic risk factor for schizophrenia and many other major
                      mental illnesses. Traditionally DISC1 has been referred to
                      as a ‘scaffold protein’ because of its ability to bind
                      to a wide array of other proteins, including those of
                      importance for neurodevelopment. Here, we review the
                      characteristic properties shared between established
                      scaffold proteins and DISC1. We find DISC1 to have many, but
                      not all, of the characteristics of a scaffold protein, as it
                      affects a considerable number of different, but related,
                      signaling pathways, in most cases through inhibition of key
                      enzymes. Using threading algorithms, the C-terminal portion
                      of DISC1 could be mapped to extended helical structures, yet
                      it may not closely resemble any of the known tertiary folds.
                      While not completely fitting the classification of a
                      classical scaffold protein, DISC1 does appear to be a
                      tightly regulated and multi-faceted inhibitor of a wide
                      range of enzymes from interrelated signaling cascades
                      (Diverse Inhibitor of Signaling Cascades), which together
                      contribute to neurodevelopment and synaptic homeostasis.
                      Consequently, disruption of this complex regulation would be
                      expected to lead to the range of major mental illnesses in
                      which the DISC1 gene has been implicated.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000325717100007},
      doi          = {10.1515/hsz-2013-0178},
      url          = {https://juser.fz-juelich.de/record/139115},
}