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@ARTICLE{Sarid:139281,
      author       = {Sarid, L. and Feldmeyer, D. and Gidon, A. and Sakmann, B.
                      and Segev, I.},
      title        = {{C}ontribution of {I}ntracolumnar {L}ayer 2/3-to-{L}ayer
                      2/3 {E}xcitatory {C}onnections in {S}haping the {R}esponse
                      to {W}hisker {D}eflection in {R}at {B}arrel {C}ortex},
      journal      = {Cerebral cortex},
      volume       = {25},
      number       = {4},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2013-05280},
      pages        = {849-858},
      year         = {2015},
      abstract     = {This computational study integrates anatomical and
                      physiological data to assess the functional role of the
                      lateral excitatory connections between layer 2/3 (L2/3)
                      pyramidal cells (PCs) in shaping their response during early
                      stages of intracortical processing of a whisker deflection
                      (WD). Based on in vivo and in vitro recordings, and 3D
                      reconstructions of connected pairs of L2/3 PCs, our model
                      predicts that: 1) AMPAR and NMDAR conductances/synapse are
                      0.52 ± 0.24 and 0.40 ± 0.34 nS, respectively; 2) following
                      WD, connection between L2/3 PCs induces a composite EPSPs of
                      7.6 ± 1.7 mV, well below the threshold for action potential
                      (AP) initiation; 3) together with the excitatory feedforward
                      L4-to-L2/3 connection, WD evoked a composite EPSP of 16.3 ±
                      3.5 mV and a probability of 0.01 to generate an AP. When
                      considering the variability in L4 spiny neurons
                      responsiveness, it increased to 17.8 ± 11.2 mV; this 3-fold
                      increase in the SD yielded AP probability of 0.35; 4) the
                      interaction between L4-to-L2/3 and L2/3-to-L2/3 inputs is
                      highly nonlinear; 5) L2/3 dendritic morphology significantly
                      affects L2/3 PCs responsiveness. We conclude that early
                      stages of intracortical signaling of WD are dominated by a
                      combination of feedforward L4–L2/3 and L2/3–L2/3 lateral
                      connections.},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000353838600002},
      doi          = {10.1093/cercor/bht268},
      url          = {https://juser.fz-juelich.de/record/139281},
}