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@ARTICLE{Florin:139282,
author = {Florin, E. and Muller, D. and Pfeiffer, J. and Barbe,
Michael and Fink, G. R. and Timmermann, L.},
title = {{S}ubthalamic stimulation modulates self-estimation of
patients with {P}arkinson’s disease and induces
risk-seeking behaviour},
journal = {Brain},
volume = {136},
number = {11},
issn = {1460-2156},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2013-05281},
pages = {3271 - 3281},
year = {2013},
abstract = {Patients with Parkinson’s disease with deep brain
stimulation in the subthalamic nucleus postoperatively often
display higher impulsivity and therefore may experience
difficulties in social interactions. Here, we examined
social interactions of patients with Parkinson’s disease
with and without deep brain stimulation in the subthalamic
nucleus in competitive situations. We hypothesized altered
self-estimation and risk-seeking behaviour in this patient
group induced by deep brain stimulation in the subthalamic
nucleus. To test the hypothesis, an experimental setting was
used in which participants performed a calculation task and
chose their preferred compensation. Based on their actual
calculation performance, more patients with Parkinson’s
disease with deep brain stimulation chose a competitive
tournament compensation. Assuming rational behaviour, this
self-selection pattern reflects increased risk tolerance.
Since patients who performed in the lowest quartile chose
the tournament option, the data suggest that deep brain
stimulation in the subthalamic nucleus results in a loss of
the correct reference frame against which patients with
Parkinson’s disease evaluate their performance. The
stimulation-induced combination of overestimation of their
own performance, increased risk-taking, and preference for
competitive environments despite poor performance is likely
to impact considerably on the patients’ social and work
life.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {333 - Pathophysiological Mechanisms of Neurological and
Psychiatric Diseases (POF2-333)},
pid = {G:(DE-HGF)POF2-333},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000326291800013},
pubmed = {pmid:24071530},
doi = {10.1093/brain/awt241},
url = {https://juser.fz-juelich.de/record/139282},
}