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000139286 1001_ $$0P:(DE-HGF)0$$avan Aerde, K. I.$$b0
000139286 245__ $$aMorphological and Physiological Characterization of Pyramidal Neuron Subtypes in Rat Medial Prefrontal Cortex
000139286 260__ $$aOxford$$bOxford Univ. Press$$c2015
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000139286 520__ $$aThe medial prefrontal cortex (mPFC) has been implicated in cognitive and executive processes including decision making, working memory and behavioral flexibility. Cortical processing depends on the interaction between distinct neuronal cell types in different cortical layers. To better understand cortical processing in the rat mPFC, we studied the diversity of pyramidal neurons using in vitro whole-cell patch clamp recordings and biocytin staining of neurons, followed by morphological analysis. Using unsupervised cluster analysis for the objective grouping of neurons, we identified more than 10 different pyramidal subtypes spread across the different cortical layers. Layer 2 pyramidal neurons possessed a unique morphology with wide apical dendritic field spans and a narrow basal field span. Layer 3 contained the only subtype that showed a burst of action potentials upon current injection. Layer 5 pyramidal neurons showed the largest voltage sags. Finally, pyramidal neurons in layer 6 (L6) showed a great variety in their morphology with 39% of L6 neurons possessing tall apical dendrites that extend into layer 1. Future experiments on the functional role of the mPFC should take into account the great diversity of pyramidal neurons. 
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000139286 7001_ $$0P:(DE-Juel1)131680$$aFeldmeyer, D.$$b1$$eCorresponding Author
000139286 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bht278$$gp. bht278$$n3$$p788-805$$tCerebral cortex$$v25$$x1460-2199$$y2015
000139286 8564_ $$uhttp://cercor.oxfordjournals.org/content/25/3/788.long
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