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@ARTICLE{vanAerde:139286,
      author       = {van Aerde, K. I. and Feldmeyer, D.},
      title        = {{M}orphological and {P}hysiological {C}haracterization of
                      {P}yramidal {N}euron {S}ubtypes in {R}at {M}edial
                      {P}refrontal {C}ortex},
      journal      = {Cerebral cortex},
      volume       = {25},
      number       = {3},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2013-05285},
      pages        = {788-805},
      year         = {2015},
      abstract     = {The medial prefrontal cortex (mPFC) has been implicated in
                      cognitive and executive processes including decision making,
                      working memory and behavioral flexibility. Cortical
                      processing depends on the interaction between distinct
                      neuronal cell types in different cortical layers. To better
                      understand cortical processing in the rat mPFC, we studied
                      the diversity of pyramidal neurons using in vitro whole-cell
                      patch clamp recordings and biocytin staining of neurons,
                      followed by morphological analysis. Using unsupervised
                      cluster analysis for the objective grouping of neurons, we
                      identified more than 10 different pyramidal subtypes spread
                      across the different cortical layers. Layer 2 pyramidal
                      neurons possessed a unique morphology with wide apical
                      dendritic field spans and a narrow basal field span. Layer 3
                      contained the only subtype that showed a burst of action
                      potentials upon current injection. Layer 5 pyramidal neurons
                      showed the largest voltage sags. Finally, pyramidal neurons
                      in layer 6 (L6) showed a great variety in their morphology
                      with $39\%$ of L6 neurons possessing tall apical dendrites
                      that extend into layer 1. Future experiments on the
                      functional role of the mPFC should take into account the
                      great diversity of pyramidal neurons.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000351935800018},
      doi          = {10.1093/cercor/bht278},
      url          = {https://juser.fz-juelich.de/record/139286},
}