000139288 001__ 139288
000139288 005__ 20210129212537.0
000139288 0247_ $$2doi$$a10.3233/JAD-131232
000139288 0247_ $$2WOS$$aWOS:000330739000018
000139288 037__ $$aFZJ-2013-05287
000139288 082__ $$a610
000139288 1001_ $$0P:(DE-Juel1)144971$$aJacobs, Heidi$$b0$$eCorresponding author$$ufzj
000139288 245__ $$aWhite matter hyperintensities are positively associated with cortical thickness in Alzheimer's disease.
000139288 260__ $$aAmsterdam$$bIOS Press$$c2014
000139288 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1392906582_14222
000139288 3367_ $$2DataCite$$aOutput Types/Journal article
000139288 3367_ $$00$$2EndNote$$aJournal Article
000139288 3367_ $$2BibTeX$$aARTICLE
000139288 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000139288 3367_ $$2DRIVER$$aarticle
000139288 500__ $$3POF3_Assignment on 2016-02-29
000139288 520__ $$aWhite matter hyperintensities are associated with an increased risk of Alzheimer's disease (AD). White matter hyperintensities are believed to disconnect brain areas. We examined the topographical association between white matter hyperintensities and cortical thickness in controls, mild cognitive impairment (MCI), and AD patients. We examined associations between white matter hyperintensities and cortical thickness among 18 older cognitively healthy participants, 18 amnestic MCI, and 17 mild AD patients. These associations were cluster-size corrected for multiple comparisons. In controls, a positive association between white matter hyperintensities and cortical thickness was found in lateral temporal gyri. In MCI patients, white matter hyperintensities were positively related to cortical thickness in frontal, temporal, and parietal areas. Positive associations between white matter hyperintensities and cortical thickness in AD patients were confined to parietal areas. The results of the interaction group by white matter hyperintensities on cortical thickness were consistent with the findings of positive associations in the parietal lobe for MCI and AD patients separately. In the frontal areas, controls and AD patients showed inverse associations between white matter hyperintensities and cortical thickness, while MCI patients still showed a positive association. These results suggest that a paradoxical relationship between white matter hyperintensities and cortical thickness could be a consequence of neuroinflammatory processes induced by AD-pathology and white matter hyperintensities. Alternatively, it might reflect a region-specific and disease-stage dependent compensatory hypertrophy in response to a compromised network.
000139288 536__ $$0G:(DE-HGF)POF2-333$$a333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333)$$cPOF2-333$$fPOF II$$x0
000139288 7001_ $$0P:(DE-HGF)0$$aClerx, L.$$b1
000139288 7001_ $$0P:(DE-HGF)0$$aGronenschild, E. H. B. M.$$b2
000139288 7001_ $$0P:(DE-HGF)0$$aAalten, P.$$b3
000139288 7001_ $$0P:(DE-HGF)0$$aVerhey, F. R. J.$$b4
000139288 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-131232$$n2$$p409-422$$tJournal of Alzheimer's disease$$v39$$x1387-2877
000139288 8564_ $$uhttps://juser.fz-juelich.de/record/139288/files/FZJ-2013-05287.pdf$$yRestricted$$zPublished final document.
000139288 909CO $$ooai:juser.fz-juelich.de:139288$$pVDB
000139288 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)144971$$aForschungszentrum Jülich GmbH$$b0$$kFZJ
000139288 9132_ $$0G:(DE-HGF)POF3-579H$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vAddenda$$x0
000139288 9131_ $$0G:(DE-HGF)POF2-333$$1G:(DE-HGF)POF2-330$$2G:(DE-HGF)POF2-300$$3G:(DE-HGF)POF2$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lFunktion und Dysfunktion des Nervensystems$$vPathophysiological Mechanisms of Neurological and Psychiatric Diseases$$x0
000139288 9141_ $$y2014
000139288 915__ $$0StatID:(DE-HGF)0040$$2StatID$$aPeer review unknown
000139288 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR
000139288 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000139288 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000139288 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000139288 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000139288 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000139288 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000139288 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000139288 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000139288 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000139288 980__ $$ajournal
000139288 980__ $$aVDB
000139288 980__ $$aUNRESTRICTED
000139288 980__ $$aI:(DE-Juel1)INM-3-20090406