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@ARTICLE{Jacobs:139288,
      author       = {Jacobs, Heidi and Clerx, L. and Gronenschild, E. H. B. M.
                      and Aalten, P. and Verhey, F. R. J.},
      title        = {{W}hite matter hyperintensities are positively associated
                      with cortical thickness in {A}lzheimer's disease.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {39},
      number       = {2},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2013-05287},
      pages        = {409-422},
      year         = {2014},
      abstract     = {White matter hyperintensities are associated with an
                      increased risk of Alzheimer's disease (AD). White matter
                      hyperintensities are believed to disconnect brain areas. We
                      examined the topographical association between white matter
                      hyperintensities and cortical thickness in controls, mild
                      cognitive impairment (MCI), and AD patients. We examined
                      associations between white matter hyperintensities and
                      cortical thickness among 18 older cognitively healthy
                      participants, 18 amnestic MCI, and 17 mild AD patients.
                      These associations were cluster-size corrected for multiple
                      comparisons. In controls, a positive association between
                      white matter hyperintensities and cortical thickness was
                      found in lateral temporal gyri. In MCI patients, white
                      matter hyperintensities were positively related to cortical
                      thickness in frontal, temporal, and parietal areas. Positive
                      associations between white matter hyperintensities and
                      cortical thickness in AD patients were confined to parietal
                      areas. The results of the interaction group by white matter
                      hyperintensities on cortical thickness were consistent with
                      the findings of positive associations in the parietal lobe
                      for MCI and AD patients separately. In the frontal areas,
                      controls and AD patients showed inverse associations between
                      white matter hyperintensities and cortical thickness, while
                      MCI patients still showed a positive association. These
                      results suggest that a paradoxical relationship between
                      white matter hyperintensities and cortical thickness could
                      be a consequence of neuroinflammatory processes induced by
                      AD-pathology and white matter hyperintensities.
                      Alternatively, it might reflect a region-specific and
                      disease-stage dependent compensatory hypertrophy in response
                      to a compromised network.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000330739000018},
      doi          = {10.3233/JAD-131232},
      url          = {https://juser.fz-juelich.de/record/139288},
}