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000139343 1001_ $$0P:(DE-Juel1)128705$$aMaybeck, Vanessa$$b0$$eCorresponding author$$ufzj
000139343 245__ $$aBoron-Doped Nanocrystalline Diamond Microelectrode Arrays Monitor Cardiac Action Potentials
000139343 260__ $$aWeinheim$$bWiley-VCH$$c2014
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000139343 520__ $$aThe expansion of diamond-based electronics in the area of biological interfacing has not been as thoroughly explored as applications in electrochemical sensing. However, the biocompatibility of diamond, large safe electrochemical window, stability, and tunable electronic properties provide opportunities to develop new devices for interfacing with electrogenic cells. Here, the fabrication of microelectrode arrays (MEAs) with boron-doped nanocrystalline diamond (BNCD) electrodes and their interfacing with cardiomyocyte-like HL-1 cells to detect cardiac action potentials are presented. A nonreductive means of structuring doped and undoped diamond on the same substrate is shown. The resulting BNCD electrodes show high stability under mechanical stress generated by the cells. It is shown that by fabricating the entire surface of the MEA with NCD, in patterns of conductive doped, and isolating undoped regions, signal detection may be improved up to four-fold over BNCD electrodes passivated with traditional isolators.
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000139343 7001_ $$0P:(DE-HGF)0$$aEdgington, Robert$$b1
000139343 7001_ $$0P:(DE-HGF)0$$aBongrain, Alexandre$$b2
000139343 7001_ $$0P:(DE-HGF)0$$aWelch, Joseph O.$$b3
000139343 7001_ $$0P:(DE-HGF)0$$aScorsone, Emanuel$$b4
000139343 7001_ $$0P:(DE-HGF)0$$aBergonzo, Philippe$$b5
000139343 7001_ $$0P:(DE-HGF)0$$aJackman, Richard B.$$b6
000139343 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b7$$ufzj
000139343 773__ $$0PERI:(DE-600)2645585-7$$a10.1002/adhm.201300062$$gp. n/a - n/a$$n2$$p283–289$$tAdvanced Healthcare Materials$$v3$$x2192-2640$$y2014
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