TY  - JOUR
AU  - Maybeck, Vanessa
AU  - Edgington, Robert
AU  - Bongrain, Alexandre
AU  - Welch, Joseph O.
AU  - Scorsone, Emanuel
AU  - Bergonzo, Philippe
AU  - Jackman, Richard B.
AU  - Offenhäusser, Andreas
TI  - Boron-Doped Nanocrystalline Diamond Microelectrode Arrays Monitor Cardiac Action Potentials
JO  - Advanced Healthcare Materials
VL  - 3
IS  - 2
SN  - 2192-2640
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2013-05340
SP  - 283–289
PY  - 2014
AB  - The expansion of diamond-based electronics in the area of biological interfacing has not been as thoroughly explored as applications in electrochemical sensing. However, the biocompatibility of diamond, large safe electrochemical window, stability, and tunable electronic properties provide opportunities to develop new devices for interfacing with electrogenic cells. Here, the fabrication of microelectrode arrays (MEAs) with boron-doped nanocrystalline diamond (BNCD) electrodes and their interfacing with cardiomyocyte-like HL-1 cells to detect cardiac action potentials are presented. A nonreductive means of structuring doped and undoped diamond on the same substrate is shown. The resulting BNCD electrodes show high stability under mechanical stress generated by the cells. It is shown that by fabricating the entire surface of the MEA with NCD, in patterns of conductive doped, and isolating undoped regions, signal detection may be improved up to four-fold over BNCD electrodes passivated with traditional isolators.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000331949000015
DO  - DOI:10.1002/adhm.201300062
UR  - https://juser.fz-juelich.de/record/139343
ER  -