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000139441 005__ 20210129212605.0
000139441 0247_ $$2doi$$a10.1523/JNEUROSCI.4714-12.2013
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000139441 1001_ $$0P:(DE-Juel1)131748$$aWeiss-Blankenhorn, Peter$$b0$$eCorresponding author$$ufzj
000139441 245__ $$aTranscranial direct current stimulation (tDCS) of left parietal cortex facilitates gesture processing in healthy subjects.
000139441 260__ $$aWashington, DC$$bSoc.$$c2013
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000139441 520__ $$aGesture processing deficits constitute a key symptom of apraxia, a disorder of motor cognition frequently observed after left-hemispheric stroke. The clinical relevance of apraxia stands in stark contrast to the paucity of therapeutic options available. Transcranial direct current stimulation (tDCS) is a promising tool for modulating disturbed network function after stroke. Here, we investigate the effect of parietal tDCS on gesture processing in healthy human subjects. Neuropsychological and imaging studies suggest that the imitation and matching of hand gestures involve the left inferior parietal lobe (IPL). Using neuronavigation based on cytoarchitectonically defined anatomical probability maps, tDCS was applied over left IPL-areas PF, PFm, or PG in healthy participants (n = 26). Before and after tDCS, subjects performed a gesture matching task and a person discrimination task for control. Changes in error rates and reaction times were analyzed for the effects of anodal and cathodal tDCS (compared with sham tDCS). Matching of hand gestures was specifically facilitated by anodal tDCS applied over the cytoarchitectonically defined IPL-area PFm, whereas tDCS over IPL-areas PF and PG did not elucidate significant effects. Taking into account tDCS electrode size and the central position of area PFm within IPL, it can be assumed that the observed effect is rather the result of a combined stimulation of the supramarginal and angular gyrus than an isolated PFm stimulation. Our data confirm the pivotal role of the left IPL in gesture processing. Furthermore, anatomically guided tDCS of the left IPL may constitute a promising approach to neurorehabilitation of apraxic patients with gesture processing deficits
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000139441 7001_ $$0P:(DE-Juel1)161332$$aAchilles, Elisabeth$$b1$$ufzj
000139441 7001_ $$0P:(DE-Juel1)140382$$aMoos, Katharina$$b2$$ufzj
000139441 7001_ $$0P:(DE-Juel1)131726$$aHesse, Maike$$b3$$ufzj
000139441 7001_ $$0P:(DE-Juel1)131742$$aSparing, Roland$$b4$$ufzj
000139441 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b5$$ufzj
000139441 773__ $$0PERI:(DE-600)1475274-8$$a10.1523/JNEUROSCI.4714-12.2013$$n49$$p19205 - 19211$$tThe @journal of neuroscience$$v33$$x0270-6474
000139441 8564_ $$uhttps://juser.fz-juelich.de/record/139441/files/FZJ-2013-05430.pdf$$yOpenAccess$$zPublished final document.
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