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@ARTICLE{WeissBlankenhorn:139441,
      author       = {Weiss-Blankenhorn, Peter and Achilles, Elisabeth and Moos,
                      Katharina and Hesse, Maike and Sparing, Roland and Fink,
                      Gereon Rudolf},
      title        = {{T}ranscranial direct current stimulation (t{DCS}) of left
                      parietal cortex facilitates gesture processing in healthy
                      subjects.},
      journal      = {The journal of neuroscience},
      volume       = {33},
      number       = {49},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2013-05430},
      pages        = {19205 - 19211},
      year         = {2013},
      abstract     = {Gesture processing deficits constitute a key symptom of
                      apraxia, a disorder of motor cognition frequently observed
                      after left-hemispheric stroke. The clinical relevance of
                      apraxia stands in stark contrast to the paucity of
                      therapeutic options available. Transcranial direct current
                      stimulation (tDCS) is a promising tool for modulating
                      disturbed network function after stroke. Here, we
                      investigate the effect of parietal tDCS on gesture
                      processing in healthy human subjects. Neuropsychological and
                      imaging studies suggest that the imitation and matching of
                      hand gestures involve the left inferior parietal lobe (IPL).
                      Using neuronavigation based on cytoarchitectonically defined
                      anatomical probability maps, tDCS was applied over left
                      IPL-areas PF, PFm, or PG in healthy participants (n = 26).
                      Before and after tDCS, subjects performed a gesture matching
                      task and a person discrimination task for control. Changes
                      in error rates and reaction times were analyzed for the
                      effects of anodal and cathodal tDCS (compared with sham
                      tDCS). Matching of hand gestures was specifically
                      facilitated by anodal tDCS applied over the
                      cytoarchitectonically defined IPL-area PFm, whereas tDCS
                      over IPL-areas PF and PG did not elucidate significant
                      effects. Taking into account tDCS electrode size and the
                      central position of area PFm within IPL, it can be assumed
                      that the observed effect is rather the result of a combined
                      stimulation of the supramarginal and angular gyrus than an
                      isolated PFm stimulation. Our data confirm the pivotal role
                      of the left IPL in gesture processing. Furthermore,
                      anatomically guided tDCS of the left IPL may constitute a
                      promising approach to neurorehabilitation of apraxic
                      patients with gesture processing deficits},
      cin          = {INM-3},
      ddc          = {590},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333)},
      pid          = {G:(DE-HGF)POF2-333},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000328110100016},
      pubmed       = {pmid:24305816},
      doi          = {10.1523/JNEUROSCI.4714-12.2013},
      url          = {https://juser.fz-juelich.de/record/139441},
}