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024 7 _ |a 10.1523/JNEUROSCI.4714-12.2013
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037 _ _ |a FZJ-2013-05430
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100 1 _ |a Weiss-Blankenhorn, Peter
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245 _ _ |a Transcranial direct current stimulation (tDCS) of left parietal cortex facilitates gesture processing in healthy subjects.
260 _ _ |a Washington, DC
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520 _ _ |a Gesture processing deficits constitute a key symptom of apraxia, a disorder of motor cognition frequently observed after left-hemispheric stroke. The clinical relevance of apraxia stands in stark contrast to the paucity of therapeutic options available. Transcranial direct current stimulation (tDCS) is a promising tool for modulating disturbed network function after stroke. Here, we investigate the effect of parietal tDCS on gesture processing in healthy human subjects. Neuropsychological and imaging studies suggest that the imitation and matching of hand gestures involve the left inferior parietal lobe (IPL). Using neuronavigation based on cytoarchitectonically defined anatomical probability maps, tDCS was applied over left IPL-areas PF, PFm, or PG in healthy participants (n = 26). Before and after tDCS, subjects performed a gesture matching task and a person discrimination task for control. Changes in error rates and reaction times were analyzed for the effects of anodal and cathodal tDCS (compared with sham tDCS). Matching of hand gestures was specifically facilitated by anodal tDCS applied over the cytoarchitectonically defined IPL-area PFm, whereas tDCS over IPL-areas PF and PG did not elucidate significant effects. Taking into account tDCS electrode size and the central position of area PFm within IPL, it can be assumed that the observed effect is rather the result of a combined stimulation of the supramarginal and angular gyrus than an isolated PFm stimulation. Our data confirm the pivotal role of the left IPL in gesture processing. Furthermore, anatomically guided tDCS of the left IPL may constitute a promising approach to neurorehabilitation of apraxic patients with gesture processing deficits
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700 1 _ |a Achilles, Elisabeth
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700 1 _ |a Moos, Katharina
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700 1 _ |a Hesse, Maike
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700 1 _ |a Sparing, Roland
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700 1 _ |a Fink, Gereon Rudolf
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773 _ _ |a 10.1523/JNEUROSCI.4714-12.2013
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856 4 _ |u https://juser.fz-juelich.de/record/139441/files/FZJ-2013-05430.pdf
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