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@ARTICLE{Filss:139444,
      author       = {Filss, Christian and Galldiks, Norbert and Stoffels,
                      Gabriele and Sabel, M. and Wittsack, H. J. and Turowski, B.
                      and Antoch, G. and Zhang, Ke and Fink, Gereon Rudolf and
                      Coenen, Heinrich Hubert and Shah, N. J. and Herzog, Hans and
                      Langen, Karl-Josef},
      title        = {{C}omparison of $^{18}${F}-{FET} {PET} and perfusion
                      weighted {MR} imaging: a {PET}-{MR} imaging hybrid study in
                      patients with brain tumors.},
      journal      = {Journal of nuclear medicine},
      volume       = {55},
      number       = {4},
      issn         = {0161-5505},
      address      = {Reston, Va.},
      publisher    = {SNM},
      reportid     = {FZJ-2013-05433},
      pages        = {540-545},
      year         = {2014},
      abstract     = {PET using O-(2-$^{18}$F-fluoroethyl)-L-tyrosine
                      ($^{18}$F-FET) provides important diagnostic information in
                      addition to that from conventional MR imaging on tumor
                      extent and activity of cerebral gliomas. Recent studies
                      suggest that perfusion-weighted MR imaging (PWI), especially
                      maps of regional cerebral blood volume (rCBV), may provide
                      similar diagnostic information. In this study, we directly
                      compared $^{18}$F-FET PET and PWI in patients with brain
                      tumors. Methods: Fifty-six patients with gliomas were
                      investigated using static $^{18}$F-FET PET and PWI. For
                      comparison, 8 patients with meningiomas were included.We
                      generated a set of tumor and reference volumes of interest
                      (VOIs) based on morphologic MR imaging and transferred these
                      VOIs to the corresponding $^{18}$F-FET PET scans and PWI
                      maps. From these VOIs, tumor-to-brain ratios (TBR) were
                      calculated, and normalized histograms were generated for
                      $^{18}$F-FET PET and rCBV maps. Furthermore, in rCBV maps
                      and in $^{18}$F-FET PET scans, tumor volumes, their spatial
                      congruence, and the distance between the local hot spots
                      were assessed. Results: For patients with glioma, TBR was
                      significantly higher in $^{18}$F-FET PET than in rCBV maps
                      (TBR, 2.28 ± 0.99 vs. 1.62 ± 1.13; P < 0.001). Histogram
                      analysis of the VOIs revealed that $^{18}$F-FET scans could
                      clearly separate tumor from background. In contrast,
                      deriving this information from rCBV maps was difficult.
                      Tumor volumes were significantly larger in $^{18}$F-FET PET
                      than in rCBV maps (tumor volume, 24.3 ± 26.5 mL vs. 8.9 ±
                      13.9 mL; P < 0.001). Accordingly, spatial overlap of both
                      imaging parameters was poor (congruence, 11.0\%), and mean
                      distance between the local hot spots was 25.4 ± 16.1 mm. In
                      meningioma patients, TBR was higher in rCBV maps than in
                      $^{18}$F-FET PET (TBR, 5.33 ± 2.63 vs. 2.37 ± 0.32; P <
                      0.001) whereas tumor volumes were comparable. Conclusion: In
                      patients with cerebral glioma, tumor imaging with
                      $^{18}$F-FET PET and rCBV yields different information.
                      $^{18}$F-FET PET shows considerably higher TBRs and larger
                      tumor volumes than rCBV maps. The spatial congruence of both
                      parameters is poor. The locations of the local hot spots
                      differ considerably. Taken together, our data show that
                      metabolically active tumor tissue of gliomas as depicted by
                      amino acid PET is not reflected by rCBV as measured with
                      PWI.},
      cin          = {INM-3 / INM-4 / INM-5 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {333 - Pathophysiological Mechanisms of Neurological and
                      Psychiatric Diseases (POF2-333) / 332 - Imaging the Living
                      Brain (POF2-332) / 89573 - Neuroimaging (POF2-89573)},
      pid          = {G:(DE-HGF)POF2-333 / G:(DE-HGF)POF2-332 /
                      G:(DE-HGF)POF2-89573},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000333910600011},
      pubmed       = {pmid:24578243},
      doi          = {10.2967/jnumed.113.129007},
      url          = {https://juser.fz-juelich.de/record/139444},
}