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@ARTICLE{Schwarten:139657,
      author       = {Schwarten, Melanie and Solyom, Z. and Feuerstein, S. and
                      Aladag, Amine and Hoffmann, Silke and Willbold, Dieter and
                      Brutscher, B.},
      title        = {{I}nteraction of {N}onstructural {P}rotein 5{A} of the
                      {H}epatitis {C} {V}irus with {S}rc {H}omology 3 {D}omains
                      {U}sing {N}oncanonical {B}inding {S}ites},
      journal      = {Biochemistry},
      volume       = {52},
      issn         = {1520-4995},
      address      = {Columbus, Ohio},
      publisher    = {American Chemical Society},
      reportid     = {FZJ-2013-05635},
      pages        = {6160-6168},
      year         = {2013},
      abstract     = {Src homology 3 (SH3) domains are widely known for their
                      ability to interact with other proteins using the canonical
                      PxxP binding motif. Besides those well-characterized
                      interaction modes, there is an increasing number of SH3
                      domain-containing complexes that lack this motif. Here we
                      characterize the interaction of SH3 domains, in particular
                      the Bin1-SH3 domain, with the intrinsically disordered part
                      of nonstructural protein 5A of the hepatitis C virus using
                      noncanonical binding sites in addition to its PxxP motif.
                      These binding regions partially overlap with regions that
                      have previously been identified as having an increased
                      propensity to form α-helices. Remarkably, upon interaction
                      with the Bin1-SH3 domain, the α-helical propensity
                      decreases and a fuzzy complex is formed.},
      cin          = {ICS-6},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000330099900004},
      doi          = {10.1021/bi400363v},
      url          = {https://juser.fz-juelich.de/record/139657},
}