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@ARTICLE{Thakur:139999,
      author       = {Thakur, Harish C. and Singh, Madhurendra and Nagel-Steger,
                      Luitgard and Prumbaum, Daniel and Fansa, Eyad Kalawy and
                      Gremer, Lothar and Ezzahoini, Hakima and Abts, André and
                      Schmitt, Lutz and Raunser, Stefan and Ahmadian, Mohammad R.
                      and Piekorz, Roland P.},
      title        = {{R}ole of centrosomal adaptor proteins of the {TACC} family
                      in the regulation of microtubule dynamics during mitotic
                      cell division},
      journal      = {Biological chemistry},
      volume       = {394},
      number       = {11},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2013-05966},
      pages        = {1411-1423},
      year         = {2013},
      abstract     = {During the mitotic division cycle, cells pass through an
                      extensive microtubule rearrangement process where
                      microtubules forming the mitotic spindle apparatus are
                      dynamically instable. Several centrosomal- and
                      microtubule-associated proteins are involved in the
                      regulation of microtubule dynamics and stability during
                      mitosis. Here, we focus on members of the transforming
                      acidic coiled coil (TACC) family of centrosomal adaptor
                      proteins, in particular TACC3, in which their subcellular
                      localization at the mitotic spindle apparatus is controlled
                      by Aurora-A kinase-mediated phosphorylation. At the effector
                      level, several TACC-binding partners have been identified
                      and characterized in greater detail, in particular, the
                      microtubule polymerase XMAP215/ch-TOG/CKAP5 and clathrin
                      heavy chain (CHC). We summarize the recent progress in the
                      molecular understanding of these TACC3 protein complexes,
                      which are crucial for proper mitotic spindle assembly and
                      dynamics to prevent faulty cell division and aneuploidy. In
                      this regard, the (patho)biological role of TACC3 in
                      development and cancer will be discussed.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000325717100006},
      doi          = {10.1515/hsz-2013-0184},
      url          = {https://juser.fz-juelich.de/record/139999},
}