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000140000 1001_ $$0P:(DE-HGF)0$$aAmin, Ehsan$$b0
000140000 245__ $$aRho-kinase: regulation, (dys)function, and inhibition
000140000 260__ $$aBerlin [u.a.]$$bde Gruyter$$c2013
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000140000 520__ $$aIn a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and adhesion plaques as well as in the regulation of transcription factors. Thus, ROCKI/II activity regulates cellular contraction, motility, morphology, polarity, cell division, and gene expression. Emerging evidence suggests that dysregulation of the Rho-ROCK pathways at different stages is linked to cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. This review focuses on the current status of understanding the multiple functions of Rho-ROCK signaling pathways and various modes of regulation of Rho-ROCK activity, thereby orchestrating a concerted functional response.
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000140000 7001_ $$0P:(DE-HGF)0$$aDubey, Badri Nath$$b1
000140000 7001_ $$0P:(DE-HGF)0$$aZhang, Si-Cai$$b2
000140000 7001_ $$0P:(DE-Juel1)145165$$aGremer, Lothar$$b3$$ufzj
000140000 7001_ $$0P:(DE-HGF)0$$aDvorsky, Radovan$$b4
000140000 7001_ $$0P:(DE-HGF)0$$aMoll, Jens M.$$b5
000140000 7001_ $$0P:(DE-HGF)0$$aTaha, Mohamed S.$$b6
000140000 7001_ $$0P:(DE-HGF)0$$aNagel-Steger, Luitgard$$b7
000140000 7001_ $$0P:(DE-HGF)0$$aPiekorz, Roland P.$$b8
000140000 7001_ $$0P:(DE-HGF)0$$aSomlyo, Avril V.$$b9
000140000 7001_ $$0P:(DE-HGF)0$$aAhmadian, Mohammad R.$$b10$$eCorresponding author
000140000 773__ $$0PERI:(DE-600)1466062-3$$a10.1515/hsz-2013-0181$$gVol. 394, no. 11$$n11$$p1399-1410$$tBiological chemistry$$v394$$x1437-4315$$y2013
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