% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Amin:140000,
      author       = {Amin, Ehsan and Dubey, Badri Nath and Zhang, Si-Cai and
                      Gremer, Lothar and Dvorsky, Radovan and Moll, Jens M. and
                      Taha, Mohamed S. and Nagel-Steger, Luitgard and Piekorz,
                      Roland P. and Somlyo, Avril V. and Ahmadian, Mohammad R.},
      title        = {{R}ho-kinase: regulation, (dys)function, and inhibition},
      journal      = {Biological chemistry},
      volume       = {394},
      number       = {11},
      issn         = {1437-4315},
      address      = {Berlin [u.a.]},
      publisher    = {de Gruyter},
      reportid     = {FZJ-2013-05967},
      pages        = {1399-1410},
      year         = {2013},
      abstract     = {In a variety of normal and pathological cell types,
                      Rho-kinases I and II (ROCKI/II) play a pivotal role in the
                      organization of the nonmuscle and smooth muscle cytoskeleton
                      and adhesion plaques as well as in the regulation of
                      transcription factors. Thus, ROCKI/II activity regulates
                      cellular contraction, motility, morphology, polarity, cell
                      division, and gene expression. Emerging evidence suggests
                      that dysregulation of the Rho-ROCK pathways at different
                      stages is linked to cardiovascular, metabolic, and
                      neurodegenerative diseases as well as cancer. This review
                      focuses on the current status of understanding the multiple
                      functions of Rho-ROCK signaling pathways and various modes
                      of regulation of Rho-ROCK activity, thereby orchestrating a
                      concerted functional response.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {452 - Structural Biology (POF2-452)},
      pid          = {G:(DE-HGF)POF2-452},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000325717100005},
      doi          = {10.1515/hsz-2013-0181},
      url          = {https://juser.fz-juelich.de/record/140000},
}