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000014031 0247_ $$2DOI$$a10.1016/j.neuroimage.2011.01.014
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000014031 041__ $$aeng
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000014031 084__ $$2WoS$$aNeurosciences
000014031 084__ $$2WoS$$aNeuroimaging
000014031 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000014031 1001_ $$0P:(DE-HGF)0$$aRehme, A.K.$$b0
000014031 245__ $$aDynamic causal modeling of cortical activity from the acute to the chronic stage after stroke
000014031 260__ $$aOrlando, Fla.$$bAcademic Press$$c2011
000014031 300__ $$a1147 - 1158
000014031 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000014031 3367_ $$2BibTeX$$aARTICLE
000014031 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000014031 3367_ $$2DRIVER$$aarticle
000014031 440_0 $$04545$$aNeuroImage$$v55$$x1053-8119$$y3
000014031 500__ $$aWe thank our volunteers and are grateful to Dr. Marc Tittgemeyer, Dr. Michael von Mengershausen, and the MR staff for support. A.K.R. and C.G. were supported by Koeln Fortune (34/2010), Faculty of Medicine, University of Cologne (Germany). S.B.E. was funded by Human Brain Project (R01-MH074457-01A1) and Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (Human Brain Model).
000014031 520__ $$aFunctional neuroimaging studies frequently demonstrated that stroke patients show bilateral activity in motor and premotor areas during movements of the paretic hand in contrast to a more lateralized activation observed in healthy subjects. Moreover, a few studies modeling functional or effective connectivity reported performance-related changes in the motor network after stroke. Here, we investigated the temporal evolution of intra- and interhemispheric (dys-) connectivity during motor recovery from the acute to the early chronic phase post-stroke. Twelve patients performed hand movements in an fMRI task in the acute (≤72 hours) and subacute stage (2 weeks) post-stroke. A subgroup of 10 patients participated in a third assessment in the early chronic stage (3-6 months). Twelve healthy subjects served as reference for brain connectivity. Changes in effective connectivity within a bilateral network comprising M1, premotor cortex (PMC), and supplementary motor area (SMA) were estimated by dynamic causal modeling. Motor performance was assessed by the Action Research Arm Test and maximum grip force. Results showed reduced positive coupling of ipsilesional SMA and PMC with ipsilesional M1 in the acute stage. Coupling parameters among these areas increased with recovery and predicted a better outcome. Likewise, negative influences from ipsilesional areas to contralesional M1 were attenuated in the acute stage. In the subacute stage, contralesional M1 exerted a positive influence on ipsilesional M1. Negative influences from ipsilesional areas on contralesional M1 subsequently normalized, but patients with poorer outcome in the chronic stage now showed enhanced negative coupling from contralesional upon ipsilesional M1. These findings show that the reinstatement of effective connectivity in the ipsilesional hemisphere is an important feature of motor recovery after stroke. The shift of an early, supportive role of contralesional M1 into enhanced inhibitory coupling might indicate maladaptive processes which could be a target of non-invasive brain stimulation techniques.
000014031 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000014031 536__ $$0G:(DE-HGF)POF2-89572$$a89572 - (Dys-)function and Plasticity (POF2-89572)$$cPOF2-89572$$fPOF II T$$x1
000014031 588__ $$aDataset connected to Web of Science, Pubmed
000014031 65320 $$2Author$$aMotor cortex
000014031 65320 $$2Author$$aLongitudinal
000014031 65320 $$2Author$$aEffective connectivity
000014031 65320 $$2Author$$aImpairment
000014031 65320 $$2Author$$aRecovery
000014031 650_2 $$2MeSH$$aAged
000014031 650_2 $$2MeSH$$aAged, 80 and over
000014031 650_2 $$2MeSH$$aBayes Theorem
000014031 650_2 $$2MeSH$$aCerebral Cortex: pathology
000014031 650_2 $$2MeSH$$aChronic Disease
000014031 650_2 $$2MeSH$$aFemale
000014031 650_2 $$2MeSH$$aForecasting
000014031 650_2 $$2MeSH$$aFunctional Laterality: physiology
000014031 650_2 $$2MeSH$$aHumans
000014031 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000014031 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000014031 650_2 $$2MeSH$$aMale
000014031 650_2 $$2MeSH$$aMiddle Aged
000014031 650_2 $$2MeSH$$aModels, Neurological
000014031 650_2 $$2MeSH$$aMotor Cortex: pathology
000014031 650_2 $$2MeSH$$aNeural Pathways: pathology
000014031 650_2 $$2MeSH$$aPrognosis
000014031 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000014031 650_2 $$2MeSH$$aRecovery of Function
000014031 650_2 $$2MeSH$$aStroke: etiology
000014031 650_2 $$2MeSH$$aStroke: pathology
000014031 650_2 $$2MeSH$$aTranscranial Magnetic Stimulation
000014031 650_7 $$2WoSType$$aJ
000014031 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S.B.$$b1$$uFZJ
000014031 7001_ $$0P:(DE-Juel1)VDB75806$$aWang, L.E.$$b2$$uFZJ
000014031 7001_ $$0P:(DE-Juel1)131720$$aFink, G.R.$$b3$$uFZJ
000014031 7001_ $$0P:(DE-Juel1)VDB500$$aGrefkes, C.$$b4$$uFZJ
000014031 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2011.01.014$$gVol. 55, p. 1147 - 1158$$p1147 - 1158$$q55<1147 - 1158$$tNeuroImage$$v55$$x1053-8119$$y2011
000014031 8567_ $$uhttp://dx.doi.org/10.1016/j.neuroimage.2011.01.014
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000014031 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000014031 9141_ $$y2011
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