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@ARTICLE{Hoffmann:14049,
      author       = {Hoffmann, Th. and Hofmann, D. and Klumpp, E. and Küppers,
                      S.},
      title        = {{E}lectrochemistry-mass spectrometry for mechanistic
                      studies and simulation of oxidation processes in the
                      environment},
      journal      = {Analytical and bioanalytical chemistry},
      volume       = {399},
      issn         = {1618-2642},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {PreJuSER-14049},
      pages        = {1859 - 1868},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Electrochemistry (EC) coupled to mass spectrometry (MS) has
                      already been successfully applied to metabolism research for
                      pharmaceutical applications, especially for the oxidation
                      behaviour of drug substances. Xenobiotics (chemicals in the
                      environment) also undergo various conversions; some of which
                      are oxidative reactions. Therefore, EC-MS might be a
                      suitable tool for the investigation of oxidative behaviour
                      of xenobiotics. A further evaluation of this approach to
                      environmental research is presented in the present paper
                      using sulfonamide antibiotics. The results with sulfadiazine
                      showed that EC-MS is a powerful tool for the elucidation of
                      the oxidative degradation mechanism within a short time
                      period. In addition, it was demonstrated that EC-MS can be
                      used as a fast and easy method to model the chemical binding
                      of xenobiotics to soil. The reaction of sulfadiazine with
                      catechol, as a model substance for organic matter in soil,
                      led to the expected chemical structure. Finally, by using
                      EC-MS a first indication was obtained of the persistence of
                      a component under chemical oxidation conditions for the
                      comparison of the oxidative stability of different classes
                      of xenobiotics. Overall, using just a few examples, the
                      study demonstrates that EC-MS can be applied as a versatile
                      tool for mechanistic studies of oxidative degradation
                      pathways of xenobiotics and their possible interaction with
                      soil organic matter as well as their oxidative stability in
                      the environment. Further studies are needed to evaluate the
                      full range of possibilities of the application of EC-MS in
                      environmental research.},
      keywords     = {Electrochemistry / Mass Spectrometry / Oxidation-Reduction
                      / Soil Pollutants: chemistry / Xenobiotics: chemistry / Soil
                      Pollutants (NLM Chemicals) / Xenobiotics (NLM Chemicals) / J
                      (WoSType)},
      cin          = {ZCH / IBG-3},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ZCH-20090406 / I:(DE-Juel1)IBG-3-20101118},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      shelfmark    = {Biochemical Research Methods / Chemistry, Analytical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21170519},
      UT           = {WOS:000286599300015},
      doi          = {10.1007/s00216-010-4575-x},
      url          = {https://juser.fz-juelich.de/record/14049},
}