TY  - JOUR
AU  - Kellermann, T.S.
AU  - Sternkopf, M.A.
AU  - Schneider, F.
AU  - Habel, U.
AU  - Turetsky, B.I.
AU  - Zilles, K.
AU  - Eickhoff, S.B.
TI  - Modulating the processing of emotional stimuli by cognitive demand
JO  - Social cognitive and affective neuroscience
VL  - 7
IS  - 3
SN  - 1749-5016
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-14083
SP  - 263-273
PY  - 2012
N1  - Record converted from VDB: 12.11.2012
AB  - Emotional processing is influenced by cognitive processes and vice versa, indicating a profound interaction of these domains. The investigation of the neural mechanisms underlying this interaction is not only highly relevant for understanding the organization of human brain function. Rather, it may also help in understanding dysregulated emotions in affective disorders and in elucidating the neurobiology of cognitive behavioural therapy (e.g. in borderline personality disorder), which aims at modulating dysfunctional emotion processes by cognitive techniques, such as restructuring. In the majority of earlier studies investigating the interaction of emotions and cognition, the main focus has been on the investigation of the effects of emotional stimuli or, more general, emotional processing, e.g. instituted by emotional material that needed to be processed, on cognitive performance and neural activation patterns. Here we pursued the opposite approach and investigated the modulation of implicit processing of emotional stimuli by cognitive demands using an event-related functional magnetic resonance imaging--study on a motor short-term memory paradigm with emotional interferences. Subjects were visually presented a finger-sequence consisting either of four (easy condition) or six (difficult condition) items, which they had to memorize. After a short pause positive, negative or neutral International affective picture system pictures or a green dot (as control condition) were presented. Subjects were instructed to reproduce the memorized sequence manually as soon as the picture disappeared. Analysis showed that with increasing cognitive demand (long relative to short sequences), neural responses to emotional pictures were significantly reduced in amygdala and orbitofrontal cortex. In contrast, the more difficult task evoked stronger activation in a widespread frontoparietal network. As stimuli were task-relevant go-cues and hence had to be processed perceptually, we would interpret this as a specific attenuation of affective responses by concurrent cognitive processing--potentially reflecting a relocation of resources mediated by the frontoparietal network.
KW  - Adult
KW  - Brain: blood supply
KW  - Brain: physiology
KW  - Brain Mapping
KW  - Cognition: physiology
KW  - Cues
KW  - Emotions: physiology
KW  - Female
KW  - Functional Laterality
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Multivariate Analysis
KW  - Neural Pathways: blood supply
KW  - Oxygen: blood
KW  - Photic Stimulation
KW  - Psychomotor Performance: physiology
KW  - Time Factors
KW  - Young Adult
KW  - Oxygen (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:21258093
C2  - pmc:PMC3304476
UR  - <Go to ISI:>//WOS:000302810100002
DO  - DOI:10.1093/scan/nsq104
UR  - https://juser.fz-juelich.de/record/14083
ER  -