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000014184 0247_ $$2pmid$$apmid:21234988
000014184 0247_ $$2DOI$$a10.1002/psc.1308
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000014184 0247_ $$2MLZ$$aAccardoMGTMRBM2011
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000014184 084__ $$2WoS$$aBiochemistry & Molecular Biology
000014184 084__ $$2WoS$$aChemistry, Analytical
000014184 1001_ $$0P:(DE-HGF)0$$aAccardo, A.$$b0
000014184 245__ $$aNanoparticles containing octeotride peptides and gadolinium complexes for MRI applications
000014184 260__ $$aNew York, NY [u.a.]$$bWiley$$c2011
000014184 300__ $$a154 - 162
000014184 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000014184 440_0 $$018981$$aJournal of Peptide Science$$v17$$x1075-2617$$y2
000014184 500__ $$aRecord converted from VDB: 12.11.2012
000014184 520__ $$aNew mixed nanoparticles were obtained by self-aggregation of two amphiplic monomers. The first monomer (C18)(2) L5-Oct contains two C18 hydrophobic moieties bound to the N-terminus of the cyclic peptide octreotide, and spaced from the bioactive peptide by five units of dioxoethylene linkers. The second monomer, (C18)(2) DTPAGlu, (C18)(2) DTPA or (C18)(2) DOTA, and the corresponding Gd(III) complexes, contains two C18 hydrophobic moieties bound through a lysine residue to different polyamino-polycarboxy ligands: DTPAGlu, DTPA or DOTA. Mixed aggregates have been obtained and structurally characterized by small angle neutron scattering (SANS) techniques and for their relaxometric behavior. According to a decrease of negative charges in the surfactant head-group, a total or a partial micelle-to-vesicle transition is observed by passing from (C18)(2) DTPAGlu to (C18)(2) DOTA. The thicknesses of the bilayers are substantially constant, around 50 Å, in the analyzed systems. Moreover, the mixed aggregates, in which a small amount of amphiphilic octreotide monomer (C18)(2) L5-Oct (10% mol/mol) was inserted, do not differ significantly from the respective self-assembled systems. Fluorescence emission of tryptophan residue at 340 nm indicates low mobility of water molecules at the peptide surface. The proton relaxivity of mixed aggregates based on (C18)(2) DTPAGlu(Gd), (C18)(2) DTPA(Gd) and (C18)(2) DOTA(Gd) resulted to be 17.6, 15.2 and 10.0 mM(-1) s(-1) (at 20 MHz and 298K), respectively. The decrease in the relaxivity values can be ascribed to the increase in τ(M) (81, 205 and 750 ns). The presence of amphiphilic octreotide monomer exposed on mixed aggregate surface gives the entire nanoparticles a potential binding selectivity toward somatostatin sstr2 receptor subtype, and these systems could act as MRI target-specific contrast agent.
000014184 536__ $$0G:(DE-Juel1)FUEK505$$2G:(DE-HGF)$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x0
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000014184 588__ $$aDataset connected to Web of Science, Pubmed
000014184 65320 $$2Author$$aamphiphilic gadolinium complexes
000014184 65320 $$2Author$$aoctreotide peptide
000014184 65320 $$2Author$$aMRI contrast agents
000014184 65320 $$2Author$$asupramolecular aggregates
000014184 65320 $$2Author$$asmall-angle neutron scattering
000014184 650_2 $$2MeSH$$aContrast Media: chemistry
000014184 650_2 $$2MeSH$$aGadolinium: chemistry
000014184 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000014184 650_2 $$2MeSH$$aNanoparticles: chemistry
000014184 650_2 $$2MeSH$$aOctreotide: chemistry
000014184 650_7 $$00$$2NLM Chemicals$$aContrast Media
000014184 650_7 $$07440-54-2$$2NLM Chemicals$$aGadolinium
000014184 650_7 $$083150-76-9$$2NLM Chemicals$$aOctreotide
000014184 650_7 $$2WoSType$$aJ
000014184 693__ $$0EXP:(DE-MLZ)KWS2-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)KWS2-20140101$$6EXP:(DE-MLZ)NL3ao-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz$$eKWS-2: Small angle scattering diffractometer$$fNL3ao$$x0
000014184 7001_ $$0P:(DE-HGF)0$$aMorisco, A.$$b1
000014184 7001_ $$0P:(DE-HGF)0$$aGianolio, E.$$b2
000014184 7001_ $$0P:(DE-HGF)0$$aTesauro, D.$$b3
000014184 7001_ $$0P:(DE-HGF)0$$aMangiapia, G.$$b4
000014184 7001_ $$0P:(DE-Juel1)VDB4342$$aRadulescu, A.$$b5$$uFZJ
000014184 7001_ $$0P:(DE-HGF)0$$aBrandt, A.$$b6
000014184 7001_ $$0P:(DE-HGF)0$$aMorelli, G.$$b7
000014184 773__ $$0PERI:(DE-600)1491819-5$$a10.1002/psc.1308$$gVol. 17, p. 154 - 162$$p154 - 162$$q17<154 - 162$$tJournal of peptide science$$v17$$x1075-2617$$y2011
000014184 8567_ $$uhttp://dx.doi.org/10.1002/psc.1308
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000014184 9141_ $$y2011
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