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@ARTICLE{Accardo:14184,
      author       = {Accardo, A. and Morisco, A. and Gianolio, E. and Tesauro,
                      D. and Mangiapia, G. and Radulescu, A. and Brandt, A. and
                      Morelli, G.},
      title        = {{N}anoparticles containing octeotride peptides and
                      gadolinium complexes for {MRI} applications},
      journal      = {Journal of peptide science},
      volume       = {17},
      issn         = {1075-2617},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {PreJuSER-14184},
      pages        = {154 - 162},
      year         = {2011},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {New mixed nanoparticles were obtained by self-aggregation
                      of two amphiplic monomers. The first monomer (C18)(2) L5-Oct
                      contains two C18 hydrophobic moieties bound to the
                      N-terminus of the cyclic peptide octreotide, and spaced from
                      the bioactive peptide by five units of dioxoethylene
                      linkers. The second monomer, (C18)(2) DTPAGlu, (C18)(2) DTPA
                      or (C18)(2) DOTA, and the corresponding Gd(III) complexes,
                      contains two C18 hydrophobic moieties bound through a lysine
                      residue to different polyamino-polycarboxy ligands: DTPAGlu,
                      DTPA or DOTA. Mixed aggregates have been obtained and
                      structurally characterized by small angle neutron scattering
                      (SANS) techniques and for their relaxometric behavior.
                      According to a decrease of negative charges in the
                      surfactant head-group, a total or a partial
                      micelle-to-vesicle transition is observed by passing from
                      (C18)(2) DTPAGlu to (C18)(2) DOTA. The thicknesses of the
                      bilayers are substantially constant, around 50 Å, in the
                      analyzed systems. Moreover, the mixed aggregates, in which a
                      small amount of amphiphilic octreotide monomer (C18)(2)
                      L5-Oct $(10\%$ mol/mol) was inserted, do not differ
                      significantly from the respective self-assembled systems.
                      Fluorescence emission of tryptophan residue at 340 nm
                      indicates low mobility of water molecules at the peptide
                      surface. The proton relaxivity of mixed aggregates based on
                      (C18)(2) DTPAGlu(Gd), (C18)(2) DTPA(Gd) and (C18)(2)
                      DOTA(Gd) resulted to be 17.6, 15.2 and 10.0 mM(-1) s(-1) (at
                      20 MHz and 298K), respectively. The decrease in the
                      relaxivity values can be ascribed to the increase in τ(M)
                      (81, 205 and 750 ns). The presence of amphiphilic octreotide
                      monomer exposed on mixed aggregate surface gives the entire
                      nanoparticles a potential binding selectivity toward
                      somatostatin sstr2 receptor subtype, and these systems could
                      act as MRI target-specific contrast agent.},
      keywords     = {Contrast Media: chemistry / Gadolinium: chemistry /
                      Magnetic Resonance Imaging: methods / Nanoparticles:
                      chemistry / Octreotide: chemistry / Contrast Media (NLM
                      Chemicals) / Gadolinium (NLM Chemicals) / Octreotide (NLM
                      Chemicals) / J (WoSType)},
      cin          = {PGI-4 / ICS-1 / Jülich Centre for Neutron Science JCNS
                      (JCNS) ; JCNS},
      ddc          = {570},
      cid          = {I:(DE-Juel1)PGI-4-20110106 / I:(DE-Juel1)ICS-1-20110106 /
                      I:(DE-Juel1)JCNS-20121112},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung / Großgeräte für die Forschung
                      mit Photonen, Neutronen und Ionen (PNI)},
      pid          = {G:(DE-Juel1)FUEK505 / G:(DE-Juel1)FUEK415},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      shelfmark    = {Biochemistry $\&$ Molecular Biology / Chemistry,
                      Analytical},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21234988},
      UT           = {WOS:000287164000013},
      doi          = {10.1002/psc.1308},
      url          = {https://juser.fz-juelich.de/record/14184},
}