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@ARTICLE{Hurlemann:1420,
      author       = {Hurlemann, R. and Schlaepfer, T.E. and Matusch, A. and
                      Reich, H. and Shah, J. N. and Zilles, K. and Maier, W. and
                      Bauer, A.},
      title        = {{R}educed 5-{HT}2{A} receptor signaling following selective
                      bilateral amygdala damage},
      journal      = {Social cognitive and affective neuroscience},
      volume       = {4},
      issn         = {1749-5016},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {PreJuSER-1420},
      pages        = {97 - 84},
      year         = {2009},
      note         = {The authors are grateful to M. X. Cohen and M. Wagner for
                      helpful comments on an earlier version of the manuscript. In
                      addition, the authors wish to thank H. H. Coenen, J. Ermert,
                      S. Grafmuller, K. Hamacher, M. Lang, B. Palm, S. Rehbein, E.
                      Wabbels (Institute of Nuclear Chemistry), D. Elmenhorst, S.
                      Sihver, M. Vogeling (Molecular Neuroimaging Group), H.
                      Herzog, S. Schaden, L. Tellmann, E. Theelen (PET
                      Instrumentation Group), B. Elghahwagi, P. Engels, G. Oefler
                      and A.-M. Oros-Peusquens (MRI Instrumentation Group,
                      Research Center Juelich). This work was supported by the
                      German Federal Ministry for Education and Research (BMBF)
                      (01GI9934); Deutsche Forschungsgemeinschaft (DFG) (Klinische
                      Forschergruppe 112 to A. B.); International Consortium for
                      Brain Mapping (ICBM). These authors contributed equally to
                      this work.},
      abstract     = {Neurobiological evidence implicates the amygdala as well as
                      serotonergic (serotonin, 5-HT) signaling via postsynaptic
                      5-HT(2A) receptors as essential substrates of anxiety
                      behaviors. Assuming a functional interdependence of these
                      substrates, we hypothesized that a low-fear behavioral
                      phenotype due to bilateral lesion of the amygdala would be
                      associated with significant 5-HT(2A) receptor changes. Thus,
                      we used [(18)F]altanserin positron emission tomography (PET)
                      referenced to radioligand plasma levels and corrected for
                      partial volume effects to quantify the spatial distribution
                      of 5-HT(2A) receptor binding potential (BP(P)) in a rare
                      patient with Urbach-Wiethe disease and selective bilateral
                      amygdala calcification damage relative to 10 healthy control
                      subjects. Consistent with our a priori hypothesis, we
                      observed a $70\%$ global decrease in 5-HT(2A) receptor BP(P)
                      in the Urbach-Wiethe patient relative to controls. Thus,
                      brain abnormalities in this patient are not restricted to
                      the amygdala, but extend to overall 5-HT neurotransmission
                      via 5-HT(2A) receptors. Our findings provide important
                      insights into the molecular architecture of human anxiety
                      behaviors and suggest the 5-HT(2A) receptor as a promising
                      pharmacological target to control pathological anxiety.},
      keywords     = {Adult / Amygdala: pathology / Amygdala: radionuclide
                      imaging / Fluorine Radioisotopes: diagnostic use / Humans /
                      Image Processing, Computer-Assisted / Ketanserin: analogs
                      $\&$ derivatives / Ketanserin: diagnostic use / Lipoid
                      Proteinosis of Urbach and Wiethe: pathology / Lipoid
                      Proteinosis of Urbach and Wiethe: psychology / Lipoid
                      Proteinosis of Urbach and Wiethe: radionuclide imaging /
                      Magnetic Resonance Imaging / Male / Neuropsychological Tests
                      / Positron-Emission Tomography / Radiopharmaceuticals:
                      diagnostic use / Receptor, Serotonin, 5-HT2A: physiology /
                      Serotonin: physiology / Synaptic Transmission / Fluorine
                      Radioisotopes (NLM Chemicals) / Radiopharmaceuticals (NLM
                      Chemicals) / Receptor, Serotonin, 5-HT2A (NLM Chemicals) /
                      Serotonin (NLM Chemicals) / Ketanserin (NLM Chemicals) /
                      altanserin (NLM Chemicals) / J (WoSType)},
      cin          = {INM-4 / INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-2-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems},
      pid          = {G:(DE-Juel1)FUEK409},
      shelfmark    = {Neurosciences / Psychology / Psychology, Experimental},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19015089},
      pmc          = {pmc:PMC2656878},
      UT           = {WOS:000264398000008},
      doi          = {10.1093/scan/nsn039},
      url          = {https://juser.fz-juelich.de/record/1420},
}