guest ::
| Home > Publications database > Reduced 5-HT2A receptor signaling following selective bilateral amygdala damage > print |
| Home > Publications database > Reduced 5-HT2A receptor signaling following selective bilateral amygdala damage > print |
| 001 | 1420 | ||
| 005 | 20180208200343.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:19015089 |
| 024 | 7 | _ | |2 pmc |a pmc:PMC2656878 |
| 024 | 7 | _ | |2 DOI |a 10.1093/scan/nsn039 |
| 024 | 7 | _ | |2 WOS |a WOS:000264398000008 |
| 037 | _ | _ | |a PreJuSER-1420 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 084 | _ | _ | |2 WoS |a Neurosciences |
| 084 | _ | _ | |2 WoS |a Psychology |
| 084 | _ | _ | |2 WoS |a Psychology, Experimental |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Hurlemann, R. |b 0 |
| 245 | _ | _ | |a Reduced 5-HT2A receptor signaling following selective bilateral amygdala damage |
| 260 | _ | _ | |a Oxford |b Oxford Univ. Press |c 2009 |
| 300 | _ | _ | |a 97 - 84 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 19361 |a Social Cognitive and Affective Neuroscience |v 4 |x 1749-5016 |y 1 |
| 500 | _ | _ | |a The authors are grateful to M. X. Cohen and M. Wagner for helpful comments on an earlier version of the manuscript. In addition, the authors wish to thank H. H. Coenen, J. Ermert, S. Grafmuller, K. Hamacher, M. Lang, B. Palm, S. Rehbein, E. Wabbels (Institute of Nuclear Chemistry), D. Elmenhorst, S. Sihver, M. Vogeling (Molecular Neuroimaging Group), H. Herzog, S. Schaden, L. Tellmann, E. Theelen (PET Instrumentation Group), B. Elghahwagi, P. Engels, G. Oefler and A.-M. Oros-Peusquens (MRI Instrumentation Group, Research Center Juelich). This work was supported by the German Federal Ministry for Education and Research (BMBF) (01GI9934); Deutsche Forschungsgemeinschaft (DFG) (Klinische Forschergruppe 112 to A. B.); International Consortium for Brain Mapping (ICBM). These authors contributed equally to this work. |
| 520 | _ | _ | |a Neurobiological evidence implicates the amygdala as well as serotonergic (serotonin, 5-HT) signaling via postsynaptic 5-HT(2A) receptors as essential substrates of anxiety behaviors. Assuming a functional interdependence of these substrates, we hypothesized that a low-fear behavioral phenotype due to bilateral lesion of the amygdala would be associated with significant 5-HT(2A) receptor changes. Thus, we used [(18)F]altanserin positron emission tomography (PET) referenced to radioligand plasma levels and corrected for partial volume effects to quantify the spatial distribution of 5-HT(2A) receptor binding potential (BP(P)) in a rare patient with Urbach-Wiethe disease and selective bilateral amygdala calcification damage relative to 10 healthy control subjects. Consistent with our a priori hypothesis, we observed a 70% global decrease in 5-HT(2A) receptor BP(P) in the Urbach-Wiethe patient relative to controls. Thus, brain abnormalities in this patient are not restricted to the amygdala, but extend to overall 5-HT neurotransmission via 5-HT(2A) receptors. Our findings provide important insights into the molecular architecture of human anxiety behaviors and suggest the 5-HT(2A) receptor as a promising pharmacological target to control pathological anxiety. |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK409 |2 G:(DE-HGF) |a Funktion und Dysfunktion des Nervensystems |c P33 |x 0 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Adult |
| 650 | _ | 2 | |2 MeSH |a Amygdala: pathology |
| 650 | _ | 2 | |2 MeSH |a Amygdala: radionuclide imaging |
| 650 | _ | 2 | |2 MeSH |a Fluorine Radioisotopes: diagnostic use |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Image Processing, Computer-Assisted |
| 650 | _ | 2 | |2 MeSH |a Ketanserin: analogs & derivatives |
| 650 | _ | 2 | |2 MeSH |a Ketanserin: diagnostic use |
| 650 | _ | 2 | |2 MeSH |a Lipoid Proteinosis of Urbach and Wiethe: pathology |
| 650 | _ | 2 | |2 MeSH |a Lipoid Proteinosis of Urbach and Wiethe: psychology |
| 650 | _ | 2 | |2 MeSH |a Lipoid Proteinosis of Urbach and Wiethe: radionuclide imaging |
| 650 | _ | 2 | |2 MeSH |a Magnetic Resonance Imaging |
| 650 | _ | 2 | |2 MeSH |a Male |
| 650 | _ | 2 | |2 MeSH |a Neuropsychological Tests |
| 650 | _ | 2 | |2 MeSH |a Positron-Emission Tomography |
| 650 | _ | 2 | |2 MeSH |a Radiopharmaceuticals: diagnostic use |
| 650 | _ | 2 | |2 MeSH |a Receptor, Serotonin, 5-HT2A: physiology |
| 650 | _ | 2 | |2 MeSH |a Serotonin: physiology |
| 650 | _ | 2 | |2 MeSH |a Synaptic Transmission |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Fluorine Radioisotopes |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Radiopharmaceuticals |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptor, Serotonin, 5-HT2A |
| 650 | _ | 7 | |0 50-67-9 |2 NLM Chemicals |a Serotonin |
| 650 | _ | 7 | |0 74050-98-9 |2 NLM Chemicals |a Ketanserin |
| 650 | _ | 7 | |0 76330-71-7 |2 NLM Chemicals |a altanserin |
| 650 | _ | 7 | |2 WoSType |a J |
| 653 | 2 | 0 | |2 Author |a Amygdala |
| 653 | 2 | 0 | |2 Author |a fear |
| 653 | 2 | 0 | |2 Author |a anxiety |
| 653 | 2 | 0 | |2 Author |a serotonin |
| 653 | 2 | 0 | |2 Author |a 5-HT2A receptor |
| 653 | 2 | 0 | |2 Author |a PET |
| 653 | 2 | 0 | |2 Author |a Urbach-Wiethe disease |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Schlaepfer, T.E. |b 1 |
| 700 | 1 | _ | |0 P:(DE-Juel1)138474 |a Matusch, A. |b 2 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Reich, H. |b 3 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131794 |a Shah, J. N. |b 4 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-Juel1)131714 |a Zilles, K. |b 5 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Maier, W. |b 6 |
| 700 | 1 | _ | |0 P:(DE-Juel1)131672 |a Bauer, A. |b 7 |u FZJ |
| 773 | _ | _ | |0 PERI:(DE-600)2236933-8 |a 10.1093/scan/nsn039 |g Vol. 4, p. 97 - 84 |p 97 - 84 |q 4<97 - 84 |t Social cognitive and affective neuroscience |v 4 |x 1749-5016 |y 2009 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656878 |
| 909 | C | O | |o oai:juser.fz-juelich.de:1420 |p VDB |
| 913 | 1 | _ | |0 G:(DE-Juel1)FUEK409 |a DE-HGF |b Gesundheit |k P33 |l Funktion und Dysfunktion des Nervensystems |v Funktion und Dysfunktion des Nervensystems |x 0 |
| 914 | 1 | _ | |y 2009 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-4-20090406 |k INM-4 |l Physik der Medizinischen Bildgebung |g INM |x 1 |
| 920 | 1 | _ | |0 I:(DE-Juel1)INM-2-20090406 |k INM-2 |l Molekulare Organisation des Gehirns |g INM |x 2 |
| 920 | 1 | _ | |0 I:(DE-82)080010_20140620 |k JARA-BRAIN |l Jülich-Aachen Research Alliance - Translational Brain Medicine |g JARA |x 3 |
| 970 | _ | _ | |a VDB:(DE-Juel1)102584 |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a ConvertedRecord |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-Juel1)INM-4-20090406 |
| 980 | _ | _ | |a I:(DE-Juel1)INM-2-20090406 |
| 980 | _ | _ | |a I:(DE-82)080010_20140620 |
| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)INM-2-20090406 |
| 981 | _ | _ | |a I:(DE-Juel1)VDB1046 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|