TY  - JOUR
AU  - Smaers, J.B.
AU  - Steele, J.
AU  - Zilles, K.
TI  - Modeling the evolution of cortico-cerebellar systems in primates
JO  - Annals of the New York Academy of Sciences
VL  - 1225
SN  - 0077-8923
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - PreJuSER-14228
SP  - 176 - 190
PY  - 2011
N1  - Record converted from VDB: 12.11.2012
AB  - Although it is commonly accepted that brains work as functionally distributed systems in which interconnected structures work together in processing particular types of information, few studies have investigated the evolution of functionally specialized neural systems across many different lineages. MR-related research has provided in-depth information on connectivity patterns, but because of its focus on particular species, it has given only indicative clues about evolutionary patterns shaping brain organization across primates. Here, we combine depth with breadth of analysis by investigating patterns of covarying size evolution in substructures of the cortico-cerebellar system across 19 anthropoid species spanning 35 million years of divergent evolution. Results demonstrate two distinct patterns of size covariation in substructures of the cortico-cerebellar system, suggesting neural systems involving profuse cortico-cerebellar connections are a major factor in explaining the evolution of anthropoid brain organization. We set out an evolutionary model of relative cortico-cerebellar expansion and provide a detailed picture of its branch-specific evolutionary history suggesting the ape radiation is the clade with the strongest and most consistent evolutionary history in relative (frontal) cortico-cerebellar expansion.
KW  - Anatomy, Comparative
KW  - Animals
KW  - Biological Evolution
KW  - Cerebellum: anatomy & histology
KW  - Cerebellum: physiology
KW  - Cerebral Cortex: anatomy & histology
KW  - Cerebral Cortex: physiology
KW  - Humans
KW  - Models, Biological
KW  - Organ Size
KW  - Organ Specificity
KW  - Phylogeny
KW  - Primates: anatomy & histology
KW  - Primates: physiology
KW  - Species Specificity
LB  - PUB:(DE-HGF)16
C6  - pmid:21535004
UR  - <Go to ISI:>//WOS:000291368900018
DO  - DOI:10.1111/j.1749-6632.2011.06003.x
UR  - https://juser.fz-juelich.de/record/14228
ER  -