TY  - JOUR
AU  - Herold, C.
AU  - Palomero-Gallagher, N.
AU  - Hellmann, B.
AU  - Kröner, S.
AU  - Theiss, C.
AU  - Güntükün, O.
AU  - Zilles, K.
TI  - The receptor architecture of the pigeons' nidopallium caudolaterale: an avian analogue to the mammalian prefrontal cortex
JO  - Brain structure & function
VL  - 216
SN  - 1863-2653
CY  - Berlin
PB  - Springer
M1  - PreJuSER-14230
SP  - 239 - 254
PY  - 2011
N1  - Supported by a grant from the BMBF through the Bernstein Focus Group "Varying Tunes'' to O.G.
AB  - The avian nidopallium caudolaterale is a multimodal area in the caudal telencephalon that is apparently not homologous to the mammalian prefrontal cortex but serves comparable functions. Here we analyzed binding-site densities of glutamatergic AMPA, NMDA and kainate receptors, GABAergic GABA(A), muscarinic M(1), M(2) and nicotinic (nACh) receptors, noradrenergic α(1) and α(2), serotonergic 5-HT(1A) and dopaminergic D(1)-like receptors using quantitative in vitro receptor autoradiography. We compared the receptor architecture of the pigeons' nidopallial structures, in particular the NCL, with cortical areas Fr2 and Cg1 in rats and prefrontal area BA10 in humans. Our results confirmed that the relative ratios of multiple receptor densities across different nidopallial structures (their "receptor fingerprints") were very similar in shape; however, the absolute binding densities (the "size" of the fingerprints) differed significantly. This finding enables a delineation of the avian NCL from surrounding structures and a further parcellation into a medial and a lateral part as revealed by differences in densities of nACh, M(2), kainate, and 5-HT(1A) receptors. Comparisons of the NCL with the rat and human frontal structures showed differences in the receptor distribution, particularly of the glutamate receptors, but also revealed highly conserved features like the identical densities of GABA(A), M(2), nACh and D(1)-like receptors. Assuming a convergent evolution of avian and mammalian prefrontal areas, our results support the hypothesis that specific neurochemical traits provide the molecular background for higher order processes such as executive functions. The differences in glutamate receptor distributions may reflect species-specific adaptations.
KW  - Animals
KW  - Autoradiography
KW  - Columbidae: anatomy & histology
KW  - Columbidae: metabolism
KW  - Densitometry
KW  - Humans
KW  - Image Processing, Computer-Assisted
KW  - Rats
KW  - Receptor, Muscarinic M1: metabolism
KW  - Receptor, Muscarinic M2: metabolism
KW  - Receptor, Serotonin, 5-HT1A: metabolism
KW  - Receptors, AMPA: metabolism
KW  - Receptors, Adrenergic: metabolism
KW  - Receptors, Dopamine D1: metabolism
KW  - Receptors, GABA-A: metabolism
KW  - Receptors, Kainic Acid: metabolism
KW  - Receptors, N-Methyl-D-Aspartate: metabolism
KW  - Receptors, Neurotransmitter: metabolism
KW  - Receptors, Nicotinic: metabolism
KW  - Species Specificity
KW  - Telencephalon: anatomy & histology
KW  - Telencephalon: metabolism
KW  - Receptor, Muscarinic M1 (NLM Chemicals)
KW  - Receptor, Muscarinic M2 (NLM Chemicals)
KW  - Receptors, AMPA (NLM Chemicals)
KW  - Receptors, Adrenergic (NLM Chemicals)
KW  - Receptors, Dopamine D1 (NLM Chemicals)
KW  - Receptors, GABA-A (NLM Chemicals)
KW  - Receptors, Kainic Acid (NLM Chemicals)
KW  - Receptors, N-Methyl-D-Aspartate (NLM Chemicals)
KW  - Receptors, Neurotransmitter (NLM Chemicals)
KW  - Receptors, Nicotinic (NLM Chemicals)
KW  - Receptor, Serotonin, 5-HT1A (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:21293877
UR  - <Go to ISI:>//WOS:000293924300007
DO  - DOI:10.1007/s00429-011-0301-5
UR  - https://juser.fz-juelich.de/record/14230
ER  -