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000014635 0247_ $$2pmid$$apmid:20048749
000014635 0247_ $$2pmc$$apmc:PMC3242031
000014635 0247_ $$2DOI$$a10.1038/mp.2009.149
000014635 0247_ $$2WOS$$aWOS:000285546400007
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000014635 041__ $$aeng
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000014635 084__ $$2WoS$$aBiochemistry & Molecular Biology
000014635 084__ $$2WoS$$aNeurosciences
000014635 084__ $$2WoS$$aPsychiatry
000014635 1001_ $$0P:(DE-HGF)0$$aSteinberg, S.$$b0
000014635 245__ $$aExpanding the range of ZNF804A variants conferring risk of psychosis
000014635 260__ $$aLondon$$bMacmillan$$c2011
000014635 300__ $$a59 - 66
000014635 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000014635 440_0 $$023741$$aMolecular Psychiatry$$v16$$x1359-4184$$y1
000014635 500__ $$aWe thank the subjects, their families and the recruitment center staff. This work was supported by the European Union (LSHM-CT-2006-037761 (Project SGENE), PIAP-GA-2008-218251 (Project PsychGene) and HEALTH-F2-2009-223423 (Project PsychCNVs)), the National Genomic Network (NGFN-2) of the German Federal Ministry of Education and Research (BMBF), the National Institute of Mental Health (R01 MH078075), the Center of Excellence for Complex Disease Genetics of the Academy of Finland (Grants 213506, 129680) and the Biocentrum Helsinki Foundation and Research Program for Molecular Medicine, Faculty of Medicine, University of Helsinki.
000014635 520__ $$aA trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P<5 × 10(-8)) associated with schizophrenia earlier. However, one variant, rs1344706[T], had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10(-7), and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10(-8). In this study, using 5164 schizophrenia cases and 20,709 controls, we replicated the association with schizophrenia (odds ratio OR = 1.08, P = 0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N = 609, OR = 1.09, P = 0.00065). Furthermore, as it has been proposed that variants such as rs1344706[T]-common and with low relative risk-may also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39,481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P = 0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P = 0.0016 for association with the larger set of psychiatric disorders).
000014635 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000014635 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
000014635 536__ $$0G:(EU-Grant)218251$$aPSYCHGENE - Copy Number Variation and Endophenotypes in Psychiatric Disorders (218251)$$c218251$$fFP7-PEOPLE-2007-3-1-IAPP$$x2
000014635 536__ $$0G:(EU-Grant)223423$$aPSYCHCNVS - Copy number variations conferring risk of psychiatric disorders in children (223423)$$c223423$$fFP7-HEALTH-2007-B$$x3
000014635 588__ $$aDataset connected to Web of Science, Pubmed
000014635 65320 $$2Author$$aschizophrenia
000014635 65320 $$2Author$$abipolar disorder
000014635 65320 $$2Author$$aZNF804A
000014635 65320 $$2Author$$aCNV
000014635 65320 $$2Author$$aassociation
000014635 650_2 $$2MeSH$$aAnxiety Disorders: genetics
000014635 650_2 $$2MeSH$$aBipolar Disorder: genetics
000014635 650_2 $$2MeSH$$aCase-Control Studies
000014635 650_2 $$2MeSH$$aDNA Copy Number Variations: genetics
000014635 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000014635 650_2 $$2MeSH$$aGenome-Wide Association Study
000014635 650_2 $$2MeSH$$aHumans
000014635 650_2 $$2MeSH$$aKruppel-Like Transcription Factors: genetics
000014635 650_2 $$2MeSH$$aReference Values
000014635 650_2 $$2MeSH$$aSchizophrenia: genetics
000014635 650_7 $$00$$2NLM Chemicals$$aKruppel-Like Transcription Factors
000014635 650_7 $$00$$2NLM Chemicals$$aZNF804A protein, human
000014635 650_7 $$2WoSType$$aJ
000014635 7001_ $$0P:(DE-HGF)0$$aMors, O.$$b1
000014635 7001_ $$0P:(DE-HGF)0$$aBorglum, A.D.$$b2
000014635 7001_ $$0P:(DE-HGF)0$$aGustafsson, O.$$b3
000014635 7001_ $$0P:(DE-HGF)0$$aWerge, T.$$b4
000014635 7001_ $$0P:(DE-HGF)0$$aMortensen, P.B.$$b5
000014635 7001_ $$0P:(DE-HGF)0$$aAndreassen, O.A.$$b6
000014635 7001_ $$0P:(DE-HGF)0$$aSigurdsson, E.$$b7
000014635 7001_ $$0P:(DE-HGF)0$$aThorgeirsson, T.E.$$b8
000014635 7001_ $$0P:(DE-HGF)0$$aBöttcher, Y.$$b9
000014635 7001_ $$0P:(DE-HGF)0$$aOlason, P.$$b10
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000014635 7001_ $$0P:(DE-HGF)0$$aGudjorsdottir, I.H.$$b13
000014635 7001_ $$0P:(DE-HGF)0$$aPietiläinen, O.P.$$b14
000014635 7001_ $$0P:(DE-HGF)0$$aNyegaard, M.$$b15
000014635 7001_ $$0P:(DE-HGF)0$$aTuulio-Henriksson, A.$$b16
000014635 7001_ $$0P:(DE-HGF)0$$aIngason, A.$$b17
000014635 7001_ $$0P:(DE-HGF)0$$aHansen, T.$$b18
000014635 7001_ $$0P:(DE-HGF)0$$aAthansiu, L.$$b19
000014635 7001_ $$0P:(DE-HGF)0$$aLuvisaari, J.$$b20
000014635 7001_ $$0P:(DE-HGF)0$$aLonnqvist, J.$$b21
000014635 7001_ $$0P:(DE-HGF)0$$aPaunio, T.$$b22
000014635 7001_ $$0P:(DE-HGF)0$$aHartmann, A.$$b23
000014635 7001_ $$0P:(DE-HGF)0$$aJürgens, G.$$b24
000014635 7001_ $$0P:(DE-HGF)0$$aNordentoft, M.$$b25
000014635 7001_ $$0P:(DE-HGF)0$$aHougaard, D.$$b26
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000014635 7001_ $$0P:(DE-HGF)0$$aGlenthoj, B.$$b31
000014635 7001_ $$0P:(DE-HGF)0$$aRasmussen, H.B.$$b32
000014635 7001_ $$0P:(DE-HGF)0$$aMattheisen, M.$$b33
000014635 7001_ $$0P:(DE-HGF)0$$aBitter, I.$$b34
000014635 7001_ $$0P:(DE-HGF)0$$aRethelyi, J.M.$$b35
000014635 7001_ $$0P:(DE-HGF)0$$aSigundsson, T.$$b36
000014635 7001_ $$0P:(DE-HGF)0$$aFossdal, R.$$b37
000014635 7001_ $$0P:(DE-HGF)0$$aThorsteinsdottir, U.$$b38
000014635 7001_ $$0P:(DE-HGF)0$$aRuggeri, M.$$b39
000014635 7001_ $$0P:(DE-HGF)0$$aTosato, S.$$b40
000014635 7001_ $$0P:(DE-HGF)0$$aStrengman, E.$$b41
000014635 7001_ $$0P:(DE-HGF)0$$aGOUP Kiemeney, L.A.$$b42
000014635 7001_ $$0P:(DE-HGF)0$$aMelle, I.$$b43
000014635 7001_ $$0P:(DE-HGF)0$$aDjurovic, S.$$b44
000014635 7001_ $$0P:(DE-HGF)0$$aAbramova, L.$$b45
000014635 7001_ $$0P:(DE-HGF)0$$aKaleda, V.$$b46
000014635 7001_ $$0P:(DE-HGF)0$$aWalshe, M.$$b47
000014635 7001_ $$0P:(DE-HGF)0$$aBramon, E.$$b48
000014635 7001_ $$0P:(DE-HGF)0$$aVassos, E.$$b49
000014635 7001_ $$0P:(DE-HGF)0$$aLi, T.$$b50
000014635 7001_ $$0P:(DE-HGF)0$$aFraser, G.$$b51
000014635 7001_ $$0P:(DE-HGF)0$$aWalker, N.$$b52
000014635 7001_ $$0P:(DE-HGF)0$$aToulopoulou, T.$$b53
000014635 7001_ $$0P:(DE-HGF)0$$aYoon, J.$$b54
000014635 7001_ $$0P:(DE-HGF)0$$aFreimer, N.B.$$b55
000014635 7001_ $$0P:(DE-HGF)0$$aCantor, R.M.$$b56
000014635 7001_ $$0P:(DE-HGF)0$$aMurray, R.$$b57
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000014635 7001_ $$0P:(DE-HGF)0$$aGolimbet, V.$$b59
000014635 7001_ $$0P:(DE-HGF)0$$aJönsson, E.G.$$b60
000014635 7001_ $$0P:(DE-HGF)0$$aTerenius, L.$$b61
000014635 7001_ $$0P:(DE-HGF)0$$aAgartz, I.$$b62
000014635 7001_ $$0P:(DE-HGF)0$$aPetursson, H.$$b63
000014635 7001_ $$0P:(DE-HGF)0$$aNöthen, M.M.$$b64
000014635 7001_ $$0P:(DE-HGF)0$$aRietschel, M.$$b65
000014635 7001_ $$0P:(DE-HGF)0$$aPeltonen, L.$$b66
000014635 7001_ $$0P:(DE-HGF)0$$aRujescu, D.$$b67
000014635 7001_ $$0P:(DE-HGF)0$$aCollier, D.A.$$b68
000014635 7001_ $$0P:(DE-HGF)0$$aStefansson, H.$$b69
000014635 7001_ $$0P:(DE-HGF)0$$aSt Clair, D.$$b70
000014635 7001_ $$0P:(DE-HGF)0$$aStefansson, K.$$b71
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